ID   LAP_BUBBU               Reviewed;          64 AA.
AC   A3RJ36;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Lingual antimicrobial peptide;
DE   Flags: Precursor;
OS   Bubalus bubalis (Domestic water buffalo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bubalus.
OX   NCBI_TaxID=89462;
RN   [1] {ECO:0000312|EMBL:ABN72271.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Udder {ECO:0000312|EMBL:ABN72271.1};
RA   Das H., More T.;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 25-64.
RC   TISSUE=Milk;
RX   PubMed=18826332; DOI=10.1177/026119290803600404;
RA   Das H., Swamy N., Sahoo G., Ahmed S.U., More T.;
RT   "Beta-defensin antibiotic peptides in the innate immunity of the buffalo:
RT   in vivo and in vitro studies.";
RL   Altern. Lab. Anim. 36:429-440(2008).
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250|UniProtKB:P46171}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. LAP/TAP subfamily.
CC       {ECO:0000255}.
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DR   EMBL; EF418028; ABN72271.1; -; mRNA.
DR   AlphaFoldDB; A3RJ36; -.
DR   SMR; A3RJ36; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:18826332"
FT   CHAIN           25..64
FT                   /note="Lingual antimicrobial peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000284619"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250|UniProtKB:P46171"
SQ   SEQUENCE   64 AA;  7041 MW;  BD24CDA3B3912F8F CRC64;
     MRLHHLLLAL LFLVLSAGSG FTQGVRNSQS CRRNKGICVP IRCPGSMRQI GTCLGAQVKC
     CRRK