ID   ARCR_HALS3              Reviewed;         263 AA.
AC   B0R9X6; Q48293;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Probable HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=OE_5209R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OG   Plasmid PHS3.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1; PLASMID=PHS3;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-263, FUNCTION, AND INDUCTION.
RC   STRAIN=R1 / S9 / L33;
RX   PubMed=8759859; DOI=10.1128/jb.178.16.4942-4947.1996;
RA   Ruepp A., Soppa J.;
RT   "Fermentative arginine degradation in Halobacterium salinarium (formerly
RT   Halobacterium halobium): genes, gene products, and transcripts of the
RT   arcRACB gene cluster.";
RL   J. Bacteriol. 178:4942-4947(1996).
CC   -!- FUNCTION: Probably regulates transcription of the arcABC operon.
CC       {ECO:0000269|PubMed:8759859}.
CC   -!- INDUCTION: No induction in fermentatively grown cells.
CC       {ECO:0000269|PubMed:8759859}.
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DR   EMBL; AM774418; CAP15557.1; -; Genomic_DNA.
DR   EMBL; X80931; CAA56903.1; -; Genomic_DNA.
DR   PIR; T44862; T44862.
DR   RefSeq; WP_010904162.1; NC_010368.1.
DR   AlphaFoldDB; B0R9X6; -.
DR   SMR; B0R9X6; -.
DR   EnsemblBacteria; CAP15557; CAP15557; OE_5209R.
DR   GeneID; 5954930; -.
DR   GeneID; 62888217; -.
DR   KEGG; hsl:OE_5209R; -.
DR   HOGENOM; CLU_062618_6_1_2; -.
DR   OMA; HTHKIMS; -.
DR   PhylomeDB; B0R9X6; -.
DR   Proteomes; UP000001321; Plasmid PHS3.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   2: Evidence at transcript level;
KW   Arginine metabolism; DNA-binding; Plasmid; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..263
FT                   /note="Probable HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000428926"
FT   DOMAIN          14..74
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DOMAIN          89..262
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   CONFLICT        70
FT                   /note="Y -> M (in Ref. 2; CAA56903)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   263 AA;  29054 MW;  6F39239CC73B9E49 CRC64;
     MDPEAANNGE PRRITSVLNA VEIIDAIKEH RGITLQELTT ELDLTKATIH TYMATLRQVG
     IVEQDGDGTY QLGDWFVPVS NYARNSTDLY RLGREEIDKL ATQTRHTAHL VTESDGRQIV
     LYESMGEESV TTEYHLRMRE TPRKLHTSAA GKSILAFLPE GRRETLISEI EFGTESSTPI
     GSPDALREQL ATVRDQGYAI NDEEEIHGIR SIGAPIRGRT EDVAGAVSVT APKTRLQNAE
     FAGEVPALVM EAANIIEVRL ETA