LAR1B_HUMAN
ID LAR1B_HUMAN Reviewed; 914 AA.
AC Q659C4; Q2YDB6; Q4W599; Q4W5B2; Q659A0; Q6P5X2; Q7Z3F7; Q86VK7; Q8N6F4;
AC Q8N7H4; Q8NAF2; Q9H5E7; Q9NW12;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=La-related protein 1B;
DE AltName: Full=La ribonucleoprotein domain family member 1B;
DE AltName: Full=La ribonucleoprotein domain family member 2;
DE AltName: Full=La-related protein 2;
GN Name=LARP1B; Synonyms=LARP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 8), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-634 (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 608-914 (ISOFORM 1), AND VARIANT ARG-462.
RC TISSUE=Lung, Small intestine, Teratocarcinoma, and Thyroid;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND VARIANTS
RP ARG-462 AND HIS-660.
RC TISSUE=Cervix, Rectum tumor, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6 AND 7), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 633-914 (ISOFORM 9), AND VARIANT HIS-660.
RC TISSUE=Blood, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-432, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-340; SER-343 AND
RP THR-454, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327; THR-329; SER-335;
RP SER-340; SER-343; THR-427; SER-436 AND THR-454, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q659C4; O00139: KIF2A; NbExp=3; IntAct=EBI-3940258, EBI-2692369;
CC Q659C4; Q86WT6: TRIM69; NbExp=3; IntAct=EBI-3940258, EBI-749955;
CC Q659C4-6; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12036449, EBI-16439278;
CC Q659C4-6; Q13084: MRPL28; NbExp=3; IntAct=EBI-12036449, EBI-723426;
CC Q659C4-6; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-12036449, EBI-14066006;
CC Q659C4-6; P47224: RABIF; NbExp=3; IntAct=EBI-12036449, EBI-713992;
CC Q659C4-6; Q8NC74: RBBP8NL; NbExp=3; IntAct=EBI-12036449, EBI-11322432;
CC Q659C4-6; Q3MII6: TBC1D25; NbExp=3; IntAct=EBI-12036449, EBI-11899977;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1;
CC IsoId=Q659C4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q659C4-2; Sequence=VSP_027642, VSP_027647;
CC Name=3;
CC IsoId=Q659C4-3; Sequence=VSP_027643, VSP_027644;
CC Name=4;
CC IsoId=Q659C4-4; Sequence=VSP_027641, VSP_027645, VSP_027646;
CC Name=5;
CC IsoId=Q659C4-5; Sequence=VSP_027640, VSP_027651;
CC Name=6;
CC IsoId=Q659C4-6; Sequence=VSP_027639, VSP_027653;
CC Name=7;
CC IsoId=Q659C4-7; Sequence=VSP_027639, VSP_027652;
CC Name=8;
CC IsoId=Q659C4-8; Sequence=VSP_027638, VSP_027650;
CC Name=9;
CC IsoId=Q659C4-9; Sequence=VSP_027648, VSP_027649;
CC -!- SIMILARITY: Belongs to the LARP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH50654.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH50654.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB15679.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAH56379.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK001240; BAA91576.1; -; mRNA.
DR EMBL; AK027164; BAB15679.1; ALT_FRAME; mRNA.
DR EMBL; AK092764; BAC03970.1; -; mRNA.
DR EMBL; AK098437; BAC05306.1; -; mRNA.
DR EMBL; AL137759; CAH56379.1; ALT_FRAME; mRNA.
DR EMBL; AL832170; CAH56210.1; -; mRNA.
DR EMBL; BX537937; CAD97908.1; -; mRNA.
DR EMBL; AC096898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC108045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC114735; AAY41042.1; -; Genomic_DNA.
DR EMBL; AC124030; AAY41031.1; -; Genomic_DNA.
DR EMBL; BC030516; AAH30516.1; -; mRNA.
DR EMBL; BC050654; AAH50654.1; ALT_SEQ; mRNA.
DR EMBL; BC062606; AAH62606.1; -; mRNA.
DR EMBL; BC110300; AAI10301.1; -; mRNA.
DR CCDS; CCDS3738.1; -. [Q659C4-1]
DR CCDS; CCDS64057.1; -. [Q659C4-3]
DR RefSeq; NP_001265533.1; NM_001278604.1. [Q659C4-3]
DR RefSeq; NP_060548.2; NM_018078.3. [Q659C4-1]
DR RefSeq; NP_115615.2; NM_032239.3.
DR RefSeq; NP_835144.1; NM_178043.2.
DR RefSeq; XP_011530371.1; XM_011532069.1. [Q659C4-2]
DR RefSeq; XP_016863842.1; XM_017008353.1. [Q659C4-3]
DR AlphaFoldDB; Q659C4; -.
DR SMR; Q659C4; -.
DR BioGRID; 120438; 157.
DR DIP; DIP-47319N; -.
DR IntAct; Q659C4; 45.
DR MINT; Q659C4; -.
DR STRING; 9606.ENSP00000321997; -.
DR GlyGen; Q659C4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q659C4; -.
DR PhosphoSitePlus; Q659C4; -.
DR BioMuta; LARP1B; -.
DR DMDM; 158564329; -.
DR CPTAC; CPTAC-1030; -.
DR EPD; Q659C4; -.
DR jPOST; Q659C4; -.
DR MassIVE; Q659C4; -.
DR MaxQB; Q659C4; -.
DR PaxDb; Q659C4; -.
DR PeptideAtlas; Q659C4; -.
DR PRIDE; Q659C4; -.
DR ProteomicsDB; 65934; -. [Q659C4-1]
DR ProteomicsDB; 65935; -. [Q659C4-2]
DR ProteomicsDB; 65936; -. [Q659C4-3]
DR ProteomicsDB; 65937; -. [Q659C4-4]
DR ProteomicsDB; 65938; -. [Q659C4-5]
DR ProteomicsDB; 65939; -. [Q659C4-6]
DR ProteomicsDB; 65940; -. [Q659C4-7]
DR ProteomicsDB; 65941; -. [Q659C4-8]
DR ProteomicsDB; 65942; -. [Q659C4-9]
DR Antibodypedia; 26972; 170 antibodies from 28 providers.
DR DNASU; 55132; -.
DR Ensembl; ENST00000326639.11; ENSP00000321997.6; ENSG00000138709.19. [Q659C4-1]
DR Ensembl; ENST00000394288.7; ENSP00000377829.3; ENSG00000138709.19. [Q659C4-3]
DR GeneID; 55132; -.
DR KEGG; hsa:55132; -.
DR MANE-Select; ENST00000326639.11; ENSP00000321997.6; NM_018078.4; NP_060548.2.
DR UCSC; uc003ify.5; human. [Q659C4-1]
DR CTD; 55132; -.
DR DisGeNET; 55132; -.
DR GeneCards; LARP1B; -.
DR HGNC; HGNC:24704; LARP1B.
DR HPA; ENSG00000138709; Low tissue specificity.
DR neXtProt; NX_Q659C4; -.
DR OpenTargets; ENSG00000138709; -.
DR PharmGKB; PA165664174; -.
DR VEuPathDB; HostDB:ENSG00000138709; -.
DR eggNOG; KOG2590; Eukaryota.
DR GeneTree; ENSGT00940000154718; -.
DR HOGENOM; CLU_003957_1_0_1; -.
DR InParanoid; Q659C4; -.
DR OMA; MVCSLPT; -.
DR OrthoDB; 258488at2759; -.
DR PhylomeDB; Q659C4; -.
DR TreeFam; TF314516; -.
DR PathwayCommons; Q659C4; -.
DR SignaLink; Q659C4; -.
DR BioGRID-ORCS; 55132; 34 hits in 1071 CRISPR screens.
DR ChiTaRS; LARP1B; human.
DR GenomeRNAi; 55132; -.
DR Pharos; Q659C4; Tdark.
DR PRO; PR:Q659C4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q659C4; protein.
DR Bgee; ENSG00000138709; Expressed in secondary oocyte and 175 other tissues.
DR ExpressionAtlas; Q659C4; baseline and differential.
DR Genevisible; Q659C4; HS.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0045727; P:positive regulation of translation; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR006607; DM15.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792; PTHR22792; 1.
DR Pfam; PF05383; La; 1.
DR SMART; SM00684; DM15; 3.
DR SMART; SM00715; LA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50961; HTH_LA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1..914
FT /note="La-related protein 1B"
FT /id="PRO_0000299411"
FT DOMAIN 209..299
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00332"
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 329
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 343
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 427
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 432
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 436
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 454
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT VAR_SEQ 1..790
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027638"
FT VAR_SEQ 1..654
FT /note="Missing (in isoform 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027639"
FT VAR_SEQ 1..581
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027640"
FT VAR_SEQ 1..194
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027641"
FT VAR_SEQ 73..120
FT /note="ANKHKWVPLHLDVVRSESQERPGSRNSSRCQPEANKPTHNNRRNDTRS ->
FT G (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027642"
FT VAR_SEQ 330..335
FT /note="ESAPNS -> VRVMIF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027643"
FT VAR_SEQ 336..914
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027644"
FT VAR_SEQ 509..522
FT /note="QEVENFKKLNLISK -> VIVSGQHLSTDALF (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027645"
FT VAR_SEQ 523..914
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027646"
FT VAR_SEQ 550..561
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027647"
FT VAR_SEQ 771..787
FT /note="YGLECLFRFYSYGLEKK -> SAVWTRKVLGLFEIFSI (in isoform
FT 9)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027648"
FT VAR_SEQ 788..914
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027649"
FT VAR_SEQ 791..806
FT /note="EIFQDFQEETKKDYES -> MRNLDNLLGKMQKKIT (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027650"
FT VAR_SEQ 850..914
FT /note="PPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSP
FT RRNISPESSDNSH -> NHHDRLLLLIINI (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027651"
FT VAR_SEQ 850..914
FT /note="PPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSP
FT RRNISPESSDNSH -> EADPIE (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027652"
FT VAR_SEQ 896..914
FT /note="VPINSPRRNISPESSDNSH -> EADPIE (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027653"
FT VARIANT 462
FT /note="P -> R (in dbSNP:rs12508837)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_034813"
FT VARIANT 660
FT /note="R -> H (in dbSNP:rs12645577)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_034814"
FT CONFLICT 272
FT /note="A -> V (in Ref. 1; BAC03970)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="K -> E (in Ref. 1; BAA91576)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="E -> T (in Ref. 1; BAC05306)"
FT /evidence="ECO:0000305"
FT CONFLICT 473
FT /note="R -> Q (in Ref. 1; BAC03970)"
FT /evidence="ECO:0000305"
FT CONFLICT 639
FT /note="T -> A (in Ref. 2; CAD97908)"
FT /evidence="ECO:0000305"
FT CONFLICT 671
FT /note="N -> S (in Ref. 4; AAH62606)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 914 AA; 105322 MW; A06968F316A432BC CRC64;
MENWPTPSEL VNTGFQSVLS QGNKKPQNRK EKEEKVEKRS NSDSKENRET KLNGPGENVS
EDEAQSSNQR KRANKHKWVP LHLDVVRSES QERPGSRNSS RCQPEANKPT HNNRRNDTRS
WKRDREKRDD QDDVSSVRSE GGNIRGSFRG RGRGRGRGRG RGRGNPRLNF DYSYGYQEHG
ERTDQPFQTE LNTSMMYYYD DGTGVQVYPV EEALLKEYIK RQIEYYFSVE NLERDFFLRG
KMDEQGFLPI SLIAGFQRVQ ALTTNLNLIL EALKDSTEVE IVDEKMRKKI EPEKWPIPGP
PPRSVPPTDF SQLIDCPEFV PGQAFCSHTE SAPNSPRIGS PLSPKKNSET SILQAMSRGL
STSLPDLDSE PWIEVKKRHQ PAPVKLRESV SVPEGSLNQL CSSEEPEQEE LDFLFDEEIE
QIGRKNTFTD WSDNDSDYEI DDQDLNKILI VTQTPPYVKK HPGGDRTGTH MSRAKITSEL
AKVINDGLYY YEQDLWMEED ENKHTAIKQE VENFKKLNLI SKEQFENLTP ELPFEPNQEV
PVAPSQSRQG GVQGVLHIPK KDLTDELAQK LFDVSEITSA AMVHSLPTAV PESPRIHPTR
TPKTPRTPRL QDPNKTPRFY PVVKEPKAID VKSPRKRKTR HSTNPPLECH VGWVMDSRDR
GPGTSSVSTS NASPSEGAPL AGSYGCTPHS FPKFQHPSHE LLKENGFTQQ VYHKYRRRCL
SERKRLGIGQ SQEMNTLFRF WSFFLRDHFN KKMYEEFRQL AWEDAKENYR YGLECLFRFY
SYGLEKKFRR EIFQDFQEET KKDYESGQLY GLEKFWAYLK YSQSKTQSID PKLQEYLCSF
KRLEDFRVDP PISDEFGRKR HSSTSGEESN RHRLPPNSST KPPNAAKPTS TSELQVPINS
PRRNISPESS DNSH
