ID   ARCR_STAA2              Reviewed;         234 AA.
AC   A6U515;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SaurJH1_2711;
OS   Staphylococcus aureus (strain JH1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=359787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JH1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.;
RT   "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT   JH1.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CP000736; ABR53533.1; -; Genomic_DNA.
DR   RefSeq; WP_000138218.1; NC_009632.1.
DR   AlphaFoldDB; A6U515; -.
DR   SMR; A6U515; -.
DR   KEGG; sah:SaurJH1_2711; -.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   OMA; EYLCKNH; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   3: Inferred from homology;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349406"
FT   DOMAIN          155..228
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        188..207
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   BINDING         40..129
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   234 AA;  27428 MW;  A63E59D8A1ED4E1E CRC64;
     MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY
     FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM
     AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLLCHLCQ TVGYDQDEFY
     EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV