ID   ARCR_STAA8              Reviewed;         234 AA.
AC   Q2FUY1; Q7X2S1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SAOUHSC_02964;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN ARGININE CATABOLISM,
RP   SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=17557828; DOI=10.1128/jb.00592-07;
RA   Makhlin J., Kofman T., Borovok I., Kohler C., Engelmann S., Cohen G.,
RA   Aharonowitz Y.;
RT   "Staphylococcus aureus arcR controls expression of the arginine deiminase
RT   operon.";
RL   J. Bacteriol. 189:5976-5986(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, by binding to the consensus motif 5'-
CC       TGTGAN(6)TCACA-3', thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP.
CC       {ECO:0000269|PubMed:17557828}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:17557828}.
CC   -!- INDUCTION: Induced by arginine and anaerobic growth during the
CC       stationary phase. Repressed under aerobic conditions independently of
CC       the growth phase and by glucose catabolic repression.
CC       {ECO:0000269|PubMed:17557828}.
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DR   EMBL; AJ566750; CAD98185.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD31954.1; -; Genomic_DNA.
DR   RefSeq; WP_000138214.1; NZ_LS483365.1.
DR   RefSeq; YP_501415.1; NC_007795.1.
DR   AlphaFoldDB; Q2FUY1; -.
DR   SMR; Q2FUY1; -.
DR   STRING; 1280.SAXN108_2902; -.
DR   EnsemblBacteria; ABD31954; ABD31954; SAOUHSC_02964.
DR   GeneID; 3921666; -.
DR   KEGG; sao:SAOUHSC_02964; -.
DR   PATRIC; fig|93061.5.peg.2674; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   OMA; EYLCKNH; -.
DR   PRO; PR:Q2FUY1; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:CACAO.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   1: Evidence at protein level;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349414"
FT   DOMAIN          155..228
FT                   /note="HTH crp-type"
FT   DNA_BIND        188..207
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         40..129
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   234 AA;  27428 MW;  A26B08D8A1EA396E CRC64;
     MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY
     FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM
     AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLICHLCQ TVGYDQDEFY
     EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV