LARMN_LACPL
ID LARMN_LACPL Reviewed; 328 AA.
AC F9USS7;
DT 27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 03-AUG-2022, entry version 46.
DE RecName: Full=Probable fused nickel transport protein LarMN {ECO:0000305};
DE AltName: Full=Probable energy-coupling factor transporter substrate-capture protein LarMN {ECO:0000305};
DE Short=ECF transporter S component LarMN {ECO:0000305};
GN Name=larMN {ECO:0000303|PubMed:24710389};
GN Synonyms=cbiM {ECO:0000312|EMBL:CCC77658.1};
GN OrderedLocusNames=lp_0102 {ECO:0000312|EMBL:CCC77658.1};
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
RN [3]
RP FUNCTION, AND INDUCTION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=24710389; DOI=10.1038/ncomms4615;
RA Desguin B., Goffin P., Viaene E., Kleerebezem M., Martin-Diaconescu V.,
RA Maroney M.J., Declercq J.P., Soumillion P., Hols P.;
RT "Lactate racemase is a nickel-dependent enzyme activated by a widespread
RT maturation system.";
RL Nat. Commun. 5:3615-3615(2014).
CC -!- FUNCTION: Probably part of the energy-coupling factor (ECF) transporter
CC complex LarMNQO involved in nickel import.
CC {ECO:0000305|PubMed:24710389}.
CC -!- SUBUNIT: May form an energy-coupling factor (ECF) transporter complex
CC composed of an ATP-binding protein (A component, LarO), a transmembrane
CC protein (T component, LarQ) and a fused possible substrate-capture
CC protein (S component, LarMN) of unknown stoichiometry. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Induced by L-lactate but not by a racemic mixture of DL-
CC lactate. Makes part of the larR(MN)QO operon.
CC {ECO:0000269|PubMed:24710389}.
CC -!- SIMILARITY: Belongs to the CbiM family. NikM subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL935263; CCC77658.1; -; Genomic_DNA.
DR RefSeq; WP_003641709.1; NC_004567.2.
DR RefSeq; YP_004888172.1; NC_004567.2.
DR AlphaFoldDB; F9USS7; -.
DR SMR; F9USS7; -.
DR STRING; 220668.lp_0102; -.
DR EnsemblBacteria; CCC77658; CCC77658; lp_0102.
DR KEGG; lpl:lp_0102; -.
DR PATRIC; fig|220668.9.peg.82; -.
DR eggNOG; COG0310; Bacteria.
DR HOGENOM; CLU_052508_2_0_9; -.
DR PhylomeDB; F9USS7; -.
DR BioCyc; LPLA220668:G1GW0-80-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR InterPro; IPR002751; CbiM/NikMN.
DR InterPro; IPR025937; PDGLE_dom.
DR Pfam; PF01891; CbiM; 1.
DR Pfam; PF13190; PDGLE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..328
FT /note="Probable fused nickel transport protein LarMN"
FT /id="PRO_0000441649"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 35166 MW; F22A8092C9B3A6CC CRC64;
MHIPDNYLSP ATCGTLVTAM APVWTVAVLK VKVQIKKHHE TLPMLGIAAS LAFLIMMFNL
PIPGGTTAHA VGGTLLAVLI GPWAACLALT VTLLLQALLF GDGGILAFGA NALNMAVIMP
FVGYACYRLG QKWHHEKLGL AIGAYLGINM AALVAGIELG LQPILAHTAS GAPLYCPYGL
NITIPAMLTA HLLVAGWVEV VFTLLVFQFV KRVAPTNLYQ TPTRRNQRPW IALLLGLAVL
SPLGLLASNT AWGEWSPQEL QQRLAQQHIS THAPQGMVHG FHFQALFSDY AIAGLPVSVG
YILSAITAVL IFLLLIRGLQ HETDTSQH
