LAS2_HUMAN
ID LAS2_HUMAN Reviewed; 372 AA.
AC Q8IYD9; I7HFJ6; Q6MZU3; Q6ZTL6;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Lung adenoma susceptibility protein 2;
DE Flags: Precursor;
GN Name=LAS2; Synonyms=C18orf54;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Urinary bladder;
RA Katagiri T., Harada Y., Nakamura Y.;
RT "Overexpression of B9838 in bladder cancers.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-372 (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Might play a role in cell proliferation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IYD9; X5D778: ANKRD11; NbExp=3; IntAct=EBI-749878, EBI-17183751;
CC Q8IYD9; Q9NXG0-2: CNTLN; NbExp=3; IntAct=EBI-749878, EBI-9640137;
CC Q8IYD9; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-749878, EBI-744099;
CC Q8IYD9; Q53GS7: GLE1; NbExp=3; IntAct=EBI-749878, EBI-1955541;
CC Q8IYD9; O75031: HSF2BP; NbExp=3; IntAct=EBI-749878, EBI-7116203;
CC Q8IYD9; P43364: MAGEA11; NbExp=4; IntAct=EBI-749878, EBI-739552;
CC Q8IYD9; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-749878, EBI-746778;
CC Q8IYD9; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-749878, EBI-5235340;
CC Q8IYD9; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-749878, EBI-6116822;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IYD9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYD9-2; Sequence=VSP_015085;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86570.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB353076; BAM34476.1; -; mRNA.
DR EMBL; AB353077; BAM34477.1; -; mRNA.
DR EMBL; AB267906; BAM35939.1; -; mRNA.
DR EMBL; BX640877; CAE45934.1; -; mRNA.
DR EMBL; CH471096; EAW63006.1; -; Genomic_DNA.
DR EMBL; BC036054; AAH36054.1; -; mRNA.
DR EMBL; AK126503; BAC86570.1; ALT_INIT; mRNA.
DR CCDS; CCDS11956.1; -. [Q8IYD9-1]
DR CCDS; CCDS74223.1; -. [Q8IYD9-2]
DR RefSeq; NP_001275909.1; NM_001288980.1. [Q8IYD9-2]
DR RefSeq; NP_001275910.1; NM_001288981.1. [Q8IYD9-2]
DR RefSeq; NP_775800.3; NM_173529.5. [Q8IYD9-1]
DR RefSeq; XP_005258258.1; XM_005258201.1.
DR RefSeq; XP_016881056.1; XM_017025567.1. [Q8IYD9-2]
DR AlphaFoldDB; Q8IYD9; -.
DR SMR; Q8IYD9; -.
DR BioGRID; 127828; 13.
DR IntAct; Q8IYD9; 12.
DR MINT; Q8IYD9; -.
DR iPTMnet; Q8IYD9; -.
DR PhosphoSitePlus; Q8IYD9; -.
DR BioMuta; C18orf54; -.
DR DMDM; 73620600; -.
DR jPOST; Q8IYD9; -.
DR MassIVE; Q8IYD9; -.
DR PaxDb; Q8IYD9; -.
DR PeptideAtlas; Q8IYD9; -.
DR PRIDE; Q8IYD9; -.
DR Antibodypedia; 22759; 101 antibodies from 16 providers.
DR DNASU; 162681; -.
DR Ensembl; ENST00000300091.5; ENSP00000300091.5; ENSG00000166845.15. [Q8IYD9-1]
DR Ensembl; ENST00000382911.8; ENSP00000372368.4; ENSG00000166845.15. [Q8IYD9-2]
DR Ensembl; ENST00000620105.5; ENSP00000477654.1; ENSG00000166845.15. [Q8IYD9-2]
DR GeneID; 162681; -.
DR KEGG; hsa:162681; -.
DR MANE-Select; ENST00000620105.5; ENSP00000477654.1; NM_001288980.2; NP_001275909.1. [Q8IYD9-2]
DR UCSC; uc002lfo.6; human. [Q8IYD9-1]
DR CTD; 162681; -.
DR DisGeNET; 162681; -.
DR GeneCards; C18orf54; -.
DR HGNC; HGNC:13796; C18orf54.
DR HPA; ENSG00000166845; Tissue enhanced (testis).
DR MIM; 613258; gene.
DR neXtProt; NX_Q8IYD9; -.
DR OpenTargets; ENSG00000166845; -.
DR PharmGKB; PA134942612; -.
DR VEuPathDB; HostDB:ENSG00000166845; -.
DR eggNOG; ENOG502RM40; Eukaryota.
DR GeneTree; ENSGT00390000008823; -.
DR HOGENOM; CLU_038585_0_0_1; -.
DR InParanoid; Q8IYD9; -.
DR OMA; SQCECEN; -.
DR OrthoDB; 597657at2759; -.
DR PhylomeDB; Q8IYD9; -.
DR TreeFam; TF337548; -.
DR PathwayCommons; Q8IYD9; -.
DR SignaLink; Q8IYD9; -.
DR BioGRID-ORCS; 162681; 8 hits in 1070 CRISPR screens.
DR ChiTaRS; C18orf54; human.
DR GenomeRNAi; 162681; -.
DR Pharos; Q8IYD9; Tbio.
DR PRO; PR:Q8IYD9; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q8IYD9; protein.
DR Bgee; ENSG00000166845; Expressed in sperm and 146 other tissues.
DR ExpressionAtlas; Q8IYD9; baseline and differential.
DR Genevisible; Q8IYD9; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR InterPro; IPR031587; LAS2.
DR Pfam; PF15792; LAS2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..372
FT /note="Lung adenoma susceptibility protein 2"
FT /id="PRO_0000019561"
FT REGION 248..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 161
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 197
FT /note="G -> GRLKNPKLMNRTNNCISESSLSFPKKSSFKDSSEHSLEKNYPRWLTS
FT QKSDLNVSGITSIPDFKYPVWLHNQDLLPDANSQRVYQIFKDDQCSPRHSHQAQGTSRL
FT INKLDCFEYAFEPSNFSNSLSDDKELVNEYKCDFEHSQCQCENPLLPGQSTKPFSG
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_015085"
FT VARIANT 147
FT /note="R -> P (in dbSNP:rs1657907)"
FT /id="VAR_050903"
FT VARIANT 196
FT /note="C -> F (in dbSNP:rs16958096)"
FT /id="VAR_050904"
FT CONFLICT 102
FT /note="K -> E (in Ref. 2; CAE45934)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="T -> I (in Ref. 2; CAE45934)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 41811 MW; F4BCD1BEA28FF61E CRC64;
MAKSKTKHRL CSQESSVSAL LASCTLSGSN SSNSDGSFHY KDKLYRSASQ ALQAYIDDFD
LGQIYPGAST GKINIDEDFT NMSQFCNYIY KPNNAFENLD HKKHSNFISC RRHTVNDIDS
MSLTTDDLLR LPADGSFSYT YVGPSHRTSK KNKKCRGRLG SLDIEKNPHF QGPYTSMGKD
NFVTPVIRSN INGKQCGDKI ELLILKAKRN LEQCTEELPK SMKKDDSPCS LDKLEADRSW
ENIPVTFKSP VPVNSDDSPQ QTSRAKSAKG VLEDFLNNDN QSCTLSGGKH HGPVEALKQM
LFNLQAVQER FNQNKTTDPK EEIKQVSEDD FSKLQLKESM IPITRSLQKA LHHLSRLRDL
VDDTNGERSP KM
