LAS2_MOUSE
ID LAS2_MOUSE Reviewed; 526 AA.
AC Q8CB14; Q8BNS5; Q8C2X0;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Lung adenoma susceptibility protein 2;
DE Flags: Precursor;
GN Name=Las2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Ovary, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19622765; DOI=10.1158/0008-5472.can-09-0782;
RA Liu P.Y., Vikis H., James M., Lu Y., Wang D.L., Liu H.B., Wen W.D.,
RA Wang Y., You M.;
RT "Identification of Las2, a major modifier gene affecting the Pas1 mouse
RT lung tumor susceptibility locus.";
RL Cancer Res. 69:6290-6298(2009).
CC -!- FUNCTION: Might play a role in cell proliferation.
CC {ECO:0000269|PubMed:19622765}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CB14-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CB14-4; Sequence=VSP_015086, VSP_015087;
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in lung and
CC spleen. Also expressed during embryonic development, at least from 7 to
CC 17 dpc. {ECO:0000269|PubMed:19622765}.
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DR EMBL; AK037066; BAC29691.1; -; mRNA.
DR EMBL; AK080780; BAC38019.1; -; mRNA.
DR EMBL; AK087788; BAC40002.1; -; mRNA.
DR EMBL; BC057927; AAH57927.1; -; mRNA.
DR CCDS; CCDS29333.1; -. [Q8CB14-1]
DR RefSeq; NP_766555.1; NM_172967.2. [Q8CB14-1]
DR AlphaFoldDB; Q8CB14; -.
DR SMR; Q8CB14; -.
DR STRING; 10090.ENSMUSP00000065118; -.
DR PhosphoSitePlus; Q8CB14; -.
DR MaxQB; Q8CB14; -.
DR PaxDb; Q8CB14; -.
DR PRIDE; Q8CB14; -.
DR Antibodypedia; 22759; 101 antibodies from 16 providers.
DR Ensembl; ENSMUST00000067556; ENSMUSP00000065118; ENSMUSG00000044906. [Q8CB14-1]
DR Ensembl; ENSMUST00000212683; ENSMUSP00000148553; ENSMUSG00000044906. [Q8CB14-4]
DR GeneID; 269033; -.
DR KEGG; mmu:269033; -.
DR UCSC; uc008fod.1; mouse. [Q8CB14-1]
DR MGI; MGI:1922045; 4930503L19Rik.
DR VEuPathDB; HostDB:ENSMUSG00000044906; -.
DR eggNOG; ENOG502RM40; Eukaryota.
DR GeneTree; ENSGT00390000008823; -.
DR HOGENOM; CLU_038585_0_0_1; -.
DR InParanoid; Q8CB14; -.
DR OMA; SQCECEN; -.
DR PhylomeDB; Q8CB14; -.
DR TreeFam; TF337548; -.
DR BioGRID-ORCS; 269033; 1 hit in 70 CRISPR screens.
DR ChiTaRS; 4930503L19Rik; mouse.
DR PRO; PR:Q8CB14; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8CB14; protein.
DR Bgee; ENSMUSG00000044906; Expressed in spermatocyte and 215 other tissues.
DR ExpressionAtlas; Q8CB14; baseline and differential.
DR Genevisible; Q8CB14; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI.
DR InterPro; IPR031587; LAS2.
DR Pfam; PF15792; LAS2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..526
FT /note="Lung adenoma susceptibility protein 2"
FT /id="PRO_0000019563"
FT REGION 150..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 161
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IYD9"
FT VAR_SEQ 352..377
FT /note="DKIELLILKAKKNLKQSAKDLPKPVE -> NILFLVFYFKAKDMLKCDILCR
FT SFMM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_015086"
FT VAR_SEQ 378..526
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_015087"
SQ SEQUENCE 526 AA; 59107 MW; 7A29E0252503DF0C CRC64;
MAKLNTKLRG CSQESSVSSL LASGSLSGSR SDSAHSAHSS FVYKDQLYSS ASEALQAYID
DFDLSREHPG ANAVKVNTDG EIGNGLQFSS YVHIPDNAFV NLDPKQHFNP LYYRRETVND
MDAISLTTDD LLRLPADGCF SFPCVPPDHR PNKKYSGRQD SSDIKNSPSF YVDATSKSKN
NIVPPYVYTN INGKKCGRPR TPKPINRENK CVSESSLSFP KESSFTEDSA ERRLENYPRW
LTSQKSDLSV SGVTSIPDVK YPIWLHNQDL LPEANTPRGY KLLNEDEYRP IHSYQTQRAN
QLLNKIDCFE YTFKPSNLTD SFSEYEGLGN EFKCQCDNPL LPGQSQKPFC GDKIELLILK
AKKNLKQSAK DLPKPVEKDD SPCSLDKLEA ERTWENVPVA FKSPVPVKAD DSPQQSSRTQ
CVNAFLEDFL NGENQSSTLS GGKHHGPVEA LKQMLFNLQT VQESFNKNKT TEPEEEIKQV
SEDDLAKLQM KENMMPITRS LHKALQHLSR LRDLVDDTSG RQSPKK
