ID   LAS2_RAT                Reviewed;         365 AA.
AC   Q66H35;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Lung adenoma susceptibility protein 2 homolog;
DE   Flags: Precursor;
GN   Name=Las2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Might play a role in cell proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; BC082051; AAH82051.1; -; mRNA.
DR   RefSeq; NP_001017462.1; NM_001017462.1.
DR   AlphaFoldDB; Q66H35; -.
DR   STRING; 10116.ENSRNOP00000014670; -.
DR   PaxDb; Q66H35; -.
DR   PRIDE; Q66H35; -.
DR   GeneID; 361346; -.
DR   KEGG; rno:361346; -.
DR   RGD; 1563837; LOC361346.
DR   VEuPathDB; HostDB:ENSRNOG00000028677; -.
DR   eggNOG; ENOG502RM40; Eukaryota.
DR   HOGENOM; CLU_038585_0_0_1; -.
DR   InParanoid; Q66H35; -.
DR   OMA; NIEHCAE; -.
DR   OrthoDB; 597657at2759; -.
DR   PRO; PR:Q66H35; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000028677; Expressed in testis and 20 other tissues.
DR   Genevisible; Q66H35; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   InterPro; IPR031587; LAS2.
DR   Pfam; PF15792; LAS2; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..365
FT                   /note="Lung adenoma susceptibility protein 2 homolog"
FT                   /id="PRO_0000019564"
FT   REGION          304..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         161
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IYD9"
SQ   SEQUENCE   365 AA;  40846 MW;  44A557A7CFE2A4E2 CRC64;
     MAKLNTKHRV CSRESSISSL LASCSLSGSS GCSSDGSFQY KDQLYSSASE ALQAYIDDFD
     LSRGHPGANT DKVNIDGEVG NGPHFSSCVL TPNNALANLD DKRHFNPLYY RRETINDMDS
     ISLTTDDLLR LPADGCFSFS HVTSDHRQKK KSKKYIGRQD SLDIKDSPSF YAPKSKDNTL
     PPYVYTNING KKCGDKIELL ILKAKKNLKQ STEDLAKPVE KDDSPCSLDK LEAERTWENV
     PVTFKSPVPV KADDSPQQNS RTKCLEDFLN DCNQSSTLSG GKHHGPVEAL KQMLFNLQAV
     QESFDQNKST EPEERRKQVS EDDFSKLQMK ENMIPITRSL HKALQHLSRL RDLVDDTSGR
     QSPKM