LASP1_CAEEL
ID LASP1_CAEEL Reviewed; 335 AA.
AC P34416; P34417; P34421; Q6AHR7;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 3.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=LIM and SH3 domain protein F42H10.3;
GN ORFNames=F42H10.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; FO080327; CCD62883.1; -; Genomic_DNA.
DR PIR; S44650; S44650.
DR PIR; S44651; S44651.
DR RefSeq; NP_498874.2; NM_066473.4.
DR AlphaFoldDB; P34416; -.
DR SMR; P34416; -.
DR BioGRID; 50445; 11.
DR IntAct; P34416; 12.
DR MINT; P34416; -.
DR STRING; 6239.F42H10.3a; -.
DR EPD; P34416; -.
DR PaxDb; P34416; -.
DR PeptideAtlas; P34416; -.
DR PRIDE; P34416; -.
DR EnsemblMetazoa; F42H10.3a.1; F42H10.3a.1; WBGene00018367.
DR GeneID; 185685; -.
DR KEGG; cel:CELE_F42H10.3; -.
DR UCSC; F42H10.3; c. elegans.
DR CTD; 185685; -.
DR WormBase; F42H10.3a; CE37108; WBGene00018367; -.
DR eggNOG; KOG1702; Eukaryota.
DR GeneTree; ENSGT00940000154775; -.
DR InParanoid; P34416; -.
DR OMA; QIEYVEY; -.
DR OrthoDB; 1549538at2759; -.
DR PhylomeDB; P34416; -.
DR PRO; PR:P34416; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00018367; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; P34416; baseline and differential.
DR GO; GO:0030054; C:cell junction; HDA:WormBase.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR000900; Nebulin_repeat.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 1.
DR Pfam; PF00880; Nebulin; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00132; LIM; 1.
DR SMART; SM00227; NEBU; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS51216; NEBULIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW LIM domain; Metal-binding; Reference proteome; Repeat; SH3 domain; Zinc.
FT CHAIN 1..335
FT /note="LIM and SH3 domain protein F42H10.3"
FT /id="PRO_0000075765"
FT DOMAIN 5..65
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REPEAT 66..97
FT /note="Nebulin 1"
FT REPEAT 98..132
FT /note="Nebulin 2"
FT DOMAIN 266..327
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 128..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 37025 MW; 77034F9E7ACCBB84 CRC64;
MSKKCAREDC GKTVYPVEEL KCLDKVWHKQ CFKCTVCGMT LNMKNYKGYD KRPYCDPHYP
KTVASVMADT PEMRRIAENT KNQSNIKYHA EYEKMKGTKI EIADDPEMER LKKNTQVQSN
VSYHGVLDQK ARQEEVRPKE EISPNPTPTP ISPMNHQSYS APTQAVAANT HLIYSTEQGG
AVSPTPQKSI GSIADYDPMN GQWGTAAAQP RNSEKLGYLK AQVDKGPARF CADFAGAPPP
SSNSISSTSP HSTLSSPQST ISPTGKAGFA VKAIYDYAAA DKDEISFLEG DIIVNCEKID
DGWMTGTVQR TLQWGMLPAN YVQPHKLPTG LHRLS
