LAT1L_HUMAN
ID LAT1L_HUMAN Reviewed; 190 AA.
AC Q9GIP4; Q6IPZ0; Q8MH62;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Putative L-type amino acid transporter 1-like protein IMAA;
DE AltName: Full=hLAT1 3-transmembrane protein IMAA;
DE Short=hLAT1 3TM IMAA;
DE AltName: Full=hLAT1 3-transmembrane protein MMAA;
DE Short=hLAT1 3TM MMAA;
GN Name=SLC7A5P2; Synonyms=IMAA, MMAA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INDUCTION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Cervix carcinoma;
RX PubMed=12009310; DOI=10.1016/s1357-2725(02)00036-5;
RA Ito M., Takebayashi S., Okumura K., Ohkubo T., Nishio M., Kawano M.,
RA Komada H., Ito Y., Tsurudome M.;
RT "Up-regulated expression of a novel gene in activated human peripheral
RT blood mononuclear cells that is a truncated paralog of the human system L-
RT amino acid transporter 1.";
RL Int. J. Biochem. Cell Biol. 34:1152-1163(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9GIP4-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9GIP4-1; Sequence=VSP_040419;
CC -!- TISSUE SPECIFICITY: Expressed in peripheral blood mononuclear cells and
CC lymphoid and myeloid cell lines. {ECO:0000269|PubMed:12009310}.
CC -!- INDUCTION: Up-regulated by concanavalin-A stimulation.
CC {ECO:0000269|PubMed:12009310}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AB040413; BAB20039.1; -; mRNA.
DR EMBL; AB055225; BAB97211.1; -; mRNA.
DR EMBL; AB055227; BAB97213.1; -; mRNA.
DR EMBL; AC005632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q9GIP4; -.
DR SMR; Q9GIP4; -.
DR iPTMnet; Q9GIP4; -.
DR PhosphoSitePlus; Q9GIP4; -.
DR BioMuta; HGNC:24951; -.
DR DMDM; 317373378; -.
DR jPOST; Q9GIP4; -.
DR MassIVE; Q9GIP4; -.
DR MaxQB; Q9GIP4; -.
DR PeptideAtlas; Q9GIP4; -.
DR PRIDE; Q9GIP4; -.
DR ProteomicsDB; 80076; -. [Q9GIP4-3]
DR ProteomicsDB; 80077; -. [Q9GIP4-1]
DR TopDownProteomics; Q9GIP4-3; -. [Q9GIP4-3]
DR GeneCards; SLC7A5P2; -.
DR HGNC; HGNC:24951; SLC7A5P2.
DR neXtProt; NX_Q9GIP4; -.
DR InParanoid; Q9GIP4; -.
DR PhylomeDB; Q9GIP4; -.
DR PathwayCommons; Q9GIP4; -.
DR ChiTaRS; SLC7A5P2; human.
DR Pharos; Q9GIP4; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9GIP4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 5: Uncertain;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..190
FT /note="Putative L-type amino acid transporter 1-like
FT protein IMAA"
FT /id="PRO_0000348250"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 180..190
FT /note="QLIVHQPTQVI -> H (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12009310"
FT /id="VSP_040419"
FT CONFLICT 26
FT /note="M -> I (in Ref. 1; BAB20039/BAB97211)"
FT /evidence="ECO:0000305"
FT CONFLICT 65
FT /note="S -> G (in Ref. 1; BAB20039/BAB97211/BAB97213)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 19840 MW; 326A92370F947AAF CRC64;
MAGAGPKRRA LAAPVAEEKE EAREKMMAAK RADGAAPAGE GEGVTLQGNI TLLKGVAVIV
VAIMSSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM
LDVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACHSVQ
LIVHQPTQVI
