LAT4_BOVIN
ID LAT4_BOVIN Reviewed; 568 AA.
AC Q0VCM6;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Large neutral amino acids transporter small subunit 4;
DE AltName: Full=L-type amino acid transporter 4;
DE AltName: Full=Solute carrier family 43 member 2;
GN Name=SLC43A2; Synonyms=LAT4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-, chloride, pH-independent high affinity transport of
CC large neutral amino acids. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
CC {ECO:0000305}.
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DR EMBL; BC120095; AAI20096.1; -; mRNA.
DR EMBL; BC147877; AAI47878.1; -; mRNA.
DR RefSeq; NP_001069014.1; NM_001075546.1.
DR AlphaFoldDB; Q0VCM6; -.
DR STRING; 9913.ENSBTAP00000015260; -.
DR PaxDb; Q0VCM6; -.
DR PRIDE; Q0VCM6; -.
DR Ensembl; ENSBTAT00000015260; ENSBTAP00000015260; ENSBTAG00000011482.
DR GeneID; 511955; -.
DR KEGG; bta:511955; -.
DR CTD; 124935; -.
DR VEuPathDB; HostDB:ENSBTAG00000011482; -.
DR VGNC; VGNC:34875; SLC43A2.
DR eggNOG; ENOG502QTQJ; Eukaryota.
DR GeneTree; ENSGT00940000153576; -.
DR HOGENOM; CLU_035676_0_0_1; -.
DR InParanoid; Q0VCM6; -.
DR OMA; TILACWF; -.
DR OrthoDB; 639867at2759; -.
DR TreeFam; TF328358; -.
DR Reactome; R-BTA-352230; Amino acid transport across the plasma membrane.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000011482; Expressed in choroid plexus and 106 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0060358; P:negative regulation of leucine import; IEA:Ensembl.
DR GO; GO:0015804; P:neutral amino acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR027201; LAT4.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR20766:SF2; PTHR20766:SF2; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..568
FT /note="Large neutral amino acids transporter small subunit
FT 4"
FT /id="PRO_0000307271"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 395..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N370"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N370"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N370"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 568 AA; 62656 MW; 32176736263F012E CRC64;
MAPTLATAHR RRWWMACTAV VENLLFSAVL LGWGSLLIML KSEGFYSYLC TEPENVTNVT
VGATAEPEHE EVSRMNGWLS CKAQDEMLNL AFTVGSFLLS AITLPLGIVM DKYGPRKLRL
LGSACFAVSC LLIAYGASNP NSLSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI
ALMIGSYASS AVTFPGVKVI YDFGASFIVI LVVWAGCSGL VFLNCFFNWP LEPFPGPEDM
DYTVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR SAKEQAALQE GHKLCLSTVD
LEVKCQPDAT AAPSFMHSVF SPILLLSLVT MCVTQLRLIF YMGAMNNILQ FLVSGDQAVV
SLYTSIFGVL QLLCLLTAPV IGYIMDWRLK ECEDASEEPE EKDANPGEKK KKRDRQIQKI
TNATRAFAFT NLLLVGFGVT CLIPNLPLQI LSFILHTIVR GFIHSAVGGL YAAVYPSTQF
GSLTGLQSLI SALFALLQQP LFLAMMGPLQ GDPLWVNVGL LVVSMLGFCL PLYLICYRRQ
LERQLERKRE DDKLFLKLNG SSNQEAFV
