LAT4_HUMAN
ID LAT4_HUMAN Reviewed; 569 AA.
AC Q8N370; B7Z6X9; C9JNU8; D3DTH9; Q5CD75; Q6IPM1; Q8NBX1; Q8NC21; Q8WZ00;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Large neutral amino acids transporter small subunit 4;
DE AltName: Full=L-type amino acid transporter 4;
DE AltName: Full=Solute carrier family 43 member 2;
GN Name=SLC43A2; Synonyms=LAT4; ORFNames=PP7664;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, AND
RP MUTAGENESIS OF SER-297.
RX PubMed=15659399; DOI=10.1074/jbc.m408638200;
RA Bodoy S., Martin L., Zorzano A., Palacin M., Estevez R., Bertran J.;
RT "Identification of LAT4, a novel amino acid transporter with system L
RT activity.";
RL J. Biol. Chem. 280:12002-12011(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Frontal cortex;
RA Shadi B., Kanai Y., Iribe Y., Chairoungdua A., Babu E., Jutabha P., Li Y.,
RA Anzai N., Endou H.;
RT "Identification of a human system L2 neutral amino acid transporter in
RT brain.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 90-569 (ISOFORM 1/2/3).
RC TISSUE=Placenta, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274 AND SER-278, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Sodium-, chloride-, and pH-independent high affinity
CC transport of large neutral amino acids. {ECO:0000269|PubMed:15659399}.
CC -!- INTERACTION:
CC Q8N370; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10265149, EBI-3867333;
CC Q8N370; Q92764: KRT35; NbExp=3; IntAct=EBI-10265149, EBI-1058674;
CC Q8N370; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10265149, EBI-11959885;
CC Q8N370; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10265149, EBI-11749135;
CC Q8N370; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10265149, EBI-22310682;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N370-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N370-2; Sequence=VSP_028665, VSP_028666;
CC Name=3;
CC IsoId=Q8N370-3; Sequence=VSP_028664;
CC Name=4;
CC IsoId=Q8N370-4; Sequence=VSP_055373, VSP_055374;
CC -!- TISSUE SPECIFICITY: Detected in several tissues with higher expression
CC in placenta, kidney and peripheral blood leukocytes. In the kidney, is
CC detected in epithelial cells of the distal tubule and collecting duct.
CC In the intestine, is expressed mainly in crypt cells of the intestinal
CC microvilli and epithelial cells in the base of the villus.
CC {ECO:0000269|PubMed:15659399}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11383.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11450.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BK005642; DAA05676.1; -; mRNA.
DR EMBL; AB120364; BAD91091.1; -; mRNA.
DR EMBL; AK075068; BAC11383.1; ALT_INIT; mRNA.
DR EMBL; AK075173; BAC11450.1; ALT_INIT; mRNA.
DR EMBL; AK301127; BAH13415.1; -; mRNA.
DR EMBL; AF289592; AAL55776.1; -; mRNA.
DR EMBL; AC100748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471108; EAW90602.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90604.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90605.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90607.1; -; Genomic_DNA.
DR EMBL; BC027923; AAH27923.1; -; mRNA.
DR EMBL; BC071859; AAH71859.1; -; mRNA.
DR CCDS; CCDS11006.1; -. [Q8N370-1]
DR CCDS; CCDS67107.1; -. [Q8N370-4]
DR CCDS; CCDS67108.1; -. [Q8N370-3]
DR RefSeq; NP_001271427.1; NM_001284498.1. [Q8N370-3]
DR RefSeq; NP_001271428.1; NM_001284499.1. [Q8N370-4]
DR RefSeq; NP_001308293.1; NM_001321364.1. [Q8N370-3]
DR RefSeq; NP_001308294.1; NM_001321365.1. [Q8N370-3]
DR RefSeq; NP_689559.1; NM_152346.2. [Q8N370-1]
DR RefSeq; XP_016879666.1; XM_017024177.1. [Q8N370-1]
DR RefSeq; XP_016879667.1; XM_017024178.1. [Q8N370-1]
DR AlphaFoldDB; Q8N370; -.
DR BioGRID; 125901; 13.
DR IntAct; Q8N370; 9.
DR MINT; Q8N370; -.
DR STRING; 9606.ENSP00000461382; -.
DR TCDB; 2.A.1.44.2; the major facilitator superfamily (mfs).
DR GlyGen; Q8N370; 3 sites.
DR iPTMnet; Q8N370; -.
DR PhosphoSitePlus; Q8N370; -.
DR BioMuta; SLC43A2; -.
DR DMDM; 74728779; -.
DR EPD; Q8N370; -.
DR jPOST; Q8N370; -.
DR MassIVE; Q8N370; -.
DR MaxQB; Q8N370; -.
DR PaxDb; Q8N370; -.
DR PeptideAtlas; Q8N370; -.
DR PRIDE; Q8N370; -.
DR ProteomicsDB; 6816; -.
DR ProteomicsDB; 71769; -. [Q8N370-1]
DR ProteomicsDB; 71770; -. [Q8N370-2]
DR ProteomicsDB; 71771; -. [Q8N370-3]
DR Antibodypedia; 10476; 114 antibodies from 20 providers.
DR DNASU; 124935; -.
DR Ensembl; ENST00000301335.10; ENSP00000301335.5; ENSG00000167703.15. [Q8N370-1]
DR Ensembl; ENST00000382147.8; ENSP00000371582.5; ENSG00000278550.4. [Q8N370-4]
DR Ensembl; ENST00000412517.3; ENSP00000408284.3; ENSG00000167703.15. [Q8N370-4]
DR Ensembl; ENST00000571650.5; ENSP00000461382.1; ENSG00000167703.15. [Q8N370-3]
DR Ensembl; ENST00000612931.4; ENSP00000483848.2; ENSG00000278550.4. [Q8N370-3]
DR Ensembl; ENST00000613070.4; ENSP00000484291.1; ENSG00000278550.4. [Q8N370-3]
DR Ensembl; ENST00000634102.1; ENSP00000488355.1; ENSG00000278550.4. [Q8N370-1]
DR GeneID; 124935; -.
DR KEGG; hsa:124935; -.
DR MANE-Select; ENST00000301335.10; ENSP00000301335.5; NM_152346.3; NP_689559.1.
DR UCSC; uc002fsu.5; human. [Q8N370-1]
DR CTD; 124935; -.
DR DisGeNET; 124935; -.
DR GeneCards; SLC43A2; -.
DR HGNC; HGNC:23087; SLC43A2.
DR HPA; ENSG00000167703; Tissue enhanced (skeletal).
DR MIM; 610791; gene.
DR neXtProt; NX_Q8N370; -.
DR OpenTargets; ENSG00000167703; -.
DR PharmGKB; PA134940765; -.
DR VEuPathDB; HostDB:ENSG00000167703; -.
DR eggNOG; ENOG502QTQJ; Eukaryota.
DR GeneTree; ENSGT00940000153576; -.
DR HOGENOM; CLU_035676_0_0_1; -.
DR InParanoid; Q8N370; -.
DR OMA; TILACWF; -.
DR OrthoDB; 639867at2759; -.
DR PhylomeDB; Q8N370; -.
DR TreeFam; TF328358; -.
DR PathwayCommons; Q8N370; -.
DR Reactome; R-HSA-352230; Amino acid transport across the plasma membrane.
DR SABIO-RK; Q8N370; -.
DR SignaLink; Q8N370; -.
DR BioGRID-ORCS; 124935; 22 hits in 1080 CRISPR screens.
DR ChiTaRS; SLC43A2; human.
DR GenomeRNAi; 124935; -.
DR Pharos; Q8N370; Tbio.
DR PRO; PR:Q8N370; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N370; protein.
DR Bgee; ENSG00000167703; Expressed in monocyte and 121 other tissues.
DR ExpressionAtlas; Q8N370; baseline and differential.
DR Genevisible; Q8N370; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; TAS:Reactome.
DR GO; GO:0051956; P:negative regulation of amino acid transport; IDA:ARUK-UCL.
DR GO; GO:0060358; P:negative regulation of leucine import; IDA:ARUK-UCL.
DR GO; GO:0015804; P:neutral amino acid transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR027201; LAT4.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR20766:SF2; PTHR20766:SF2; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Amino-acid transport; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..569
FT /note="Large neutral amino acids transporter small subunit
FT 4"
FT /id="PRO_0000307272"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 395..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 560
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..30
FT /note="MAPTLATAHRRRWWMACTAVLENLLFSAVL -> MTYGSPQANASPSDAVAL
FT DHGEVSRRQQQE (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055373"
FT VAR_SEQ 31..167
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055374"
FT VAR_SEQ 358
FT /note="K -> KTVMA (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028664"
FT VAR_SEQ 407..489
FT /note="GEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHT
FT IVRGFIHSAVGGLYAAVYPSTQFGSLTGLQS -> CVGRAGAPAPSPQPLQKDPRAACQ
FT AQGGWDRGREQCTPAPPGALRETHSFSSACVSTAPLFMEIVWNAMEMLKFEARCGDSCL
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15498874"
FT /id="VSP_028665"
FT VAR_SEQ 490..569
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15498874"
FT /id="VSP_028666"
FT MUTAGEN 297
FT /note="S->A: Abolishes sensitivity to N-ethymaleimide."
FT /evidence="ECO:0000269|PubMed:15659399"
FT CONFLICT 19
FT /note="A -> P (in Ref. 4; AAL55776)"
FT /evidence="ECO:0000305"
FT CONFLICT 254
FT /note="D -> N (in Ref. 3; BAC11383)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 569 AA; 62747 MW; 86C4BB53FF849881 CRC64;
MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC TEPENVTNGT
VGGTAEPGHE EVSWMNGWLS CQAQDEMLNL AFTVGSFLLS AITLPLGIVM DKYGPRKLRL
LGSACFAVSC LLIAYGASKP NALSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI
ALMIGSYASS AVTFPGIKLI YDAGVSFIVV LVVWAGCSGL VFLNCFFNWP LEPFPGPEDM
DYSVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR SAKEQVALQE GHKLCLSTVD
LEVKCQPDAA VAPSFMHSVF SPILLLSLVT MCVTQLRLIF YMGAMNNILK FLVSGDQKTV
GLYTSIFGVL QLLCLLTAPV IGYIMDWRLK ECEDASEEPE EKDANQGEKK KKKRDRQIQK
ITNAMRAFAF TNLLLVGFGV TCLIPNLPLQ ILSFILHTIV RGFIHSAVGG LYAAVYPSTQ
FGSLTGLQSL ISALFALLQQ PLFLAMMGPL QGDPLWVNVG LLLLSLLGFC LPLYLICYRR
QLERQLQQRQ EDDKLFLKIN GSSNQEAFV
