ID   LAT4_XENTR              Reviewed;         568 AA.
AC   A4IHK6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Large neutral amino acids transporter small subunit 4;
DE   AltName: Full=L-type amino acid transporter 4;
DE   AltName: Full=Solute carrier family 43 member 2;
GN   Name=slc43a2; Synonyms=lat4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-, chloride, pH-independent high affinity transport of
CC       large neutral amino acids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
CC       {ECO:0000305}.
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DR   EMBL; BC135570; AAI35571.1; -; mRNA.
DR   RefSeq; NP_001096206.1; NM_001102736.1.
DR   AlphaFoldDB; A4IHK6; -.
DR   STRING; 8364.ENSXETP00000048213; -.
DR   PaxDb; A4IHK6; -.
DR   GeneID; 100124757; -.
DR   KEGG; xtr:100124757; -.
DR   CTD; 124935; -.
DR   Xenbase; XB-GENE-987892; slc43a2.
DR   eggNOG; ENOG502QTQJ; Eukaryota.
DR   InParanoid; A4IHK6; -.
DR   OrthoDB; 639867at2759; -.
DR   Reactome; R-XTR-352230; Amino acid transport across the plasma membrane.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015804; P:neutral amino acid transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR027201; LAT4.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR20766:SF2; PTHR20766:SF2; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..568
FT                   /note="Large neutral amino acids transporter small subunit
FT                   4"
FT                   /id="PRO_0000307275"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        516..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        55
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   568 AA;  63139 MW;  899699E287D54968 CRC64;
     MAPTLATAHR RRWWMACTAV VENLFFSAVL LGWGSLLIML KSEGFYSYLC HYPDNTTYHN
     STGNETNQEL VMDMNGWLIC KEQDEMLNLA FTVGSFLLSA ISLPLGIIMD KYGPRKLRLS
     GSASFGVSCL LIAYGASNPN SLSVLIFVAL CLNGFGGMCM TFTSLTLPNM FGDLRSTFIA
     LMIGSYASSA VTFPFIKVIY DLGVSFITIL IVWAACAGLV FFNCFFNWPL EPFPGPEDMD
     YTVKIKFSWL GFDHKITGKQ FYKQVTTVGR RLSVGGSMKN PKELSALQNG NKLCLSTVDL
     EVKCQADNAA TPSFMKSVFS PILLLSLITM CVTQLRLIFY MGAMNNILEF LVEGDMDTVS
     LYTSIFGVLQ LLCLLTAPVI GYIMDWKLKD CDDGKEDADE KDTNTDGKKK KKRDRQIQKI
     TNATRAFAFT NFLLVGFGIT CLINNLPLQI LSFILHTIVR GFIHSAVGGL YAAVYPSTHF
     GSLTGLQSLI SALFALLQQP LFLAMMGPLE GDPLWVNVGL LGVSMFGFCL PLYLIFYKRS
     LERQRKQKIE DSKLYLKING TPDHEAFV