ID   ARCR_STAAS              Reviewed;         234 AA.
AC   Q6G643;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SAS2517;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BX571857; CAG44334.1; -; Genomic_DNA.
DR   RefSeq; WP_000138213.1; NC_002953.3.
DR   AlphaFoldDB; Q6G643; -.
DR   SMR; Q6G643; -.
DR   KEGG; sas:SAS2517; -.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   OMA; EYLCKNH; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   3: Inferred from homology;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..234
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349409"
FT   DOMAIN          155..228
FT                   /note="HTH crp-type"
FT   DNA_BIND        188..207
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         40..129
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   234 AA;  27463 MW;  AE94FBD8A1E3A0FE CRC64;
     MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY
     FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM
     AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLFCHLCQ TVGYDQDEFY
     EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV