LATE_ARATH
ID LATE_ARATH Reviewed; 173 AA.
AC Q9FKA9;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein LATE FLOWERING {ECO:0000303|PubMed:21771123};
GN Name=LATE {ECO:0000303|PubMed:21771123};
GN OrderedLocusNames=At5g48890 {ECO:0000312|Araport:AT5G48890};
GN ORFNames=K24G6.23 {ECO:0000303|PubMed:9734815};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15236668; DOI=10.1186/1471-2164-5-39;
RA Englbrecht C.C., Schoof H., Boehm S.;
RT "Conservation, diversification and expansion of C2H2 zinc finger proteins
RT in the Arabidopsis thaliana genome.";
RL BMC Genomics 5:39-39(2004).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=21771123; DOI=10.1111/j.1365-313x.2011.04717.x;
RA Weingartner M., Subert C., Sauer N.;
RT "LATE, a C(2)H(2) zinc-finger protein that acts as floral repressor.";
RL Plant J. 68:681-692(2011).
CC -!- FUNCTION: Acts as a transcriptional repressor. Prevents the
CC photoperiodic and circadian clock-dependent transition to flowering in
CC long days (LD) by repressing the expression of flowering time genes
CC (e.g. FT, GI and CO) in the leaf vasculature, and by interfering with
CC floral meristem identity genes at the apex (e.g. SOC1 and LFY).
CC {ECO:0000269|PubMed:21771123}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21771123}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in leaves and flower buds, and, to
CC a lower extent, in seedlings and shoot apex, but not in roots and
CC floral primordia. {ECO:0000269|PubMed:21771123}.
CC -!- DEVELOPMENTAL STAGE: In seedlings, present in cotyledons and in the
CC hypocotyl. Later expressed specifically in the leaf vasculature, the
CC vegetative shoot apical meristem and emerging leaf primordia. At the
CC onset of flowering, observed at the shoot apex, but excluded from the
CC first visible floral buds of the bolting inflorescence. In flowers,
CC confined to the vasculature of the sepals.
CC {ECO:0000269|PubMed:21771123}.
CC -!- DOMAIN: Contains a slightly degenerated ERF-associated amphiphilic
CC repression (EAR) motif, which may be involved in the activity of
CC transcriptional repression. {ECO:0000250|UniProtKB:O80340}.
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DR EMBL; AB012242; BAB09442.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95739.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68632.1; -; Genomic_DNA.
DR RefSeq; NP_001318765.1; NM_001344809.1.
DR RefSeq; NP_199700.1; NM_124266.2.
DR AlphaFoldDB; Q9FKA9; -.
DR SMR; Q9FKA9; -.
DR IntAct; Q9FKA9; 5.
DR STRING; 3702.AT5G48890.1; -.
DR PaxDb; Q9FKA9; -.
DR PRIDE; Q9FKA9; -.
DR DNASU; 834947; -.
DR EnsemblPlants; AT5G48890.1; AT5G48890.1; AT5G48890.
DR EnsemblPlants; AT5G48890.2; AT5G48890.2; AT5G48890.
DR GeneID; 834947; -.
DR Gramene; AT5G48890.1; AT5G48890.1; AT5G48890.
DR Gramene; AT5G48890.2; AT5G48890.2; AT5G48890.
DR KEGG; ath:AT5G48890; -.
DR Araport; AT5G48890; -.
DR TAIR; locus:2156529; AT5G48890.
DR eggNOG; ENOG502R5Q8; Eukaryota.
DR HOGENOM; CLU_090167_0_0_1; -.
DR InParanoid; Q9FKA9; -.
DR OMA; CFQASHT; -.
DR OrthoDB; 1426485at2759; -.
DR PhylomeDB; Q9FKA9; -.
DR PRO; PR:Q9FKA9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKA9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0009910; P:negative regulation of flower development; IMP:UniProtKB.
DR GO; GO:0048579; P:negative regulation of long-day photoperiodism, flowering; IMP:TAIR.
DR GO; GO:0042752; P:regulation of circadian rhythm; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045320; JAGGED/KNUCKLES-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45730; PTHR45730; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Flowering; Metal-binding; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..173
FT /note="Protein LATE FLOWERING"
FT /id="PRO_0000435544"
FT ZN_FING 35..57
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 167..171
FT /note="EAR-like (transcriptional repression)"
FT /evidence="ECO:0000250|UniProtKB:O80340"
SQ SEQUENCE 173 AA; 19448 MW; 441FFF645B70351B CRC64;
MEDHYHQVEV EGEEEIKPSK EANKTDENTS SLRIFPCLFC SRKFHSSQAL GGHQNAHKKE
RTAARRAKRA YDFVNNNDFL HTLPVFLSSP SQHHLTILGY PASASVACFP TVHPDHPIFK
SSGSHVVLAT SHQGRDCKGG YCCQQRVDIL DHHYNVVNSD KGKDQCLDLS LHL
