ARCR_STAAW
ID ARCR_STAAW Reviewed; 234 AA.
AC Q8NUK9;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=HTH-type transcriptional regulator ArcR;
GN Name=arcR; OrderedLocusNames=MW2552;
OS Staphylococcus aureus (strain MW2).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=196620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MW2;
RX PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT "Genome and virulence determinants of high virulence community-acquired
RT MRSA.";
RL Lancet 359:1819-1827(2002).
CC -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC under anaerobic conditions, thus playing an essential role in arginine
CC catabolism. May also control the expression of genes encoding proteins
CC which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; BA000033; BAB96417.1; -; Genomic_DNA.
DR RefSeq; WP_000138213.1; NC_003923.1.
DR AlphaFoldDB; Q8NUK9; -.
DR SMR; Q8NUK9; -.
DR EnsemblBacteria; BAB96417; BAB96417; BAB96417.
DR KEGG; sam:MW2552; -.
DR HOGENOM; CLU_1160528_0_0_9; -.
DR OMA; EYLCKNH; -.
DR Proteomes; UP000000418; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR012318; HTH_CRP.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF13545; HTH_Crp_2; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
PE 3: Inferred from homology;
KW Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW Transcription; Transcription regulation.
FT CHAIN 1..234
FT /note="HTH-type transcriptional regulator ArcR"
FT /id="PRO_0000349412"
FT DOMAIN 155..228
FT /note="HTH crp-type"
FT DNA_BIND 188..207
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT BINDING 40..129
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
SQ SEQUENCE 234 AA; 27463 MW; AE94FBD8A1E3A0FE CRC64;
MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY FSPQESSNIY
FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV NELCTALTDC TVLGLPRELM
AFLCKANDDI FLTLFALIND NEQQHMNYNM ALTSKFAKDR IIKLFCHLCQ TVGYDQDEFY
EIKQFLTIQL MSDMAGISRE TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV