LAT_MYCBO
ID LAT_MYCBO Reviewed; 449 AA.
AC P63510; A0A1R3Y3U5; P96895; X2BNI6;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Probable L-lysine-epsilon aminotransferase;
DE Short=L-lysine aminotransferase;
DE EC=2.6.1.36;
DE AltName: Full=Lysine 6-aminotransferase;
GN Name=lat; OrderedLocusNames=BQ2027_MB3318C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-
CC glutamate; Xref=Rhea:RHEA:21200, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:32551, ChEBI:CHEBI:58321; EC=2.6.1.36;
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT708304; SIU01947.1; -; Genomic_DNA.
DR RefSeq; NP_856963.1; NC_002945.3.
DR RefSeq; WP_003900004.1; NC_002945.4.
DR AlphaFoldDB; P63510; -.
DR SMR; P63510; -.
DR EnsemblBacteria; SIU01947; SIU01947; BQ2027_MB3318C.
DR PATRIC; fig|233413.5.peg.3647; -.
DR OMA; DPPDMVT; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0045484; F:L-lysine 6-transaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR CDD; cd00610; OAT_like; 1.
DR Gene3D; 3.40.640.10; -; 1.
DR Gene3D; 3.90.1150.10; -; 1.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR017657; L-lysine_6-transaminase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR Pfam; PF00202; Aminotran_3; 1.
DR PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR SUPFAM; SSF53383; SSF53383; 1.
DR TIGRFAMs; TIGR03251; LAT_fam; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE 3: Inferred from homology;
KW Aminotransferase; Pyridoxal phosphate; Transferase.
FT CHAIN 1..449
FT /note="Probable L-lysine-epsilon aminotransferase"
FT /id="PRO_0000120513"
FT MOD_RES 300
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 449 AA; 49012 MW; 9A1739F61C6D6049 CRC64;
MAAVVKSVAL AGRPTTPDRV HEVLGRSMLV DGLDIVLDLT RSGGSYLVDA ITGRRYLDMF
TFVASSALGM NPPALVDDRE FHAELMQAAL NKPSNSDVYS VAMARFVETF ARVLGDPALP
HLFFVEGGAL AVENALKAAF DWKSRHNQAH GIDPALGTQV LHLRGAFHGR SGYTLSLTNT
KPTITARFPK FDWPRIDAPY MRPGLDEPAM AALEAEALRQ ARAAFETRPH DIACFVAEPI
QGEGGDRHFR PEFFAAMREL CDEFDALLIF DEVQTGCGLT GTAWAYQQLD VAPDIVAFGK
KTQVCGVMAG RRVDEVADNV FAVPSRLNST WGGNLTDMVR ARRILEVIEA EGLFERAVQH
GKYLRARLDE LAADFPAVVL DPRGRGLMCA FSLPTTADRD ELIRQLWQRA VIVLPAGADT
VRFRPPLTVS TAEIDAAIAA VRSALPVVT