ID   LAT_MYCTO               Reviewed;         449 AA.
AC   P9WQ76; L0TF67; P63509; P96895;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Probable L-lysine-epsilon aminotransferase;
DE            Short=L-lysine aminotransferase;
DE            EC=2.6.1.36;
DE   AltName: Full=Lysine 6-aminotransferase;
GN   Name=lat; OrderedLocusNames=MT3389;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-
CC         glutamate; Xref=Rhea:RHEA:21200, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:32551, ChEBI:CHEBI:58321; EC=2.6.1.36;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK47732.1; -; Genomic_DNA.
DR   PIR; C70981; C70981.
DR   RefSeq; WP_003900004.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WQ76; -.
DR   SMR; P9WQ76; -.
DR   EnsemblBacteria; AAK47732; AAK47732; MT3389.
DR   KEGG; mtc:MT3389; -.
DR   PATRIC; fig|83331.31.peg.3647; -.
DR   HOGENOM; CLU_016922_10_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0045484; F:L-lysine 6-transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR017657; L-lysine_6-transaminase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR03251; LAT_fam; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE   3: Inferred from homology;
KW   Aminotransferase; Pyridoxal phosphate; Transferase.
FT   CHAIN           1..449
FT                   /note="Probable L-lysine-epsilon aminotransferase"
FT                   /id="PRO_0000426824"
FT   MOD_RES         300
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  49012 MW;  9A1739F61C6D6049 CRC64;
     MAAVVKSVAL AGRPTTPDRV HEVLGRSMLV DGLDIVLDLT RSGGSYLVDA ITGRRYLDMF
     TFVASSALGM NPPALVDDRE FHAELMQAAL NKPSNSDVYS VAMARFVETF ARVLGDPALP
     HLFFVEGGAL AVENALKAAF DWKSRHNQAH GIDPALGTQV LHLRGAFHGR SGYTLSLTNT
     KPTITARFPK FDWPRIDAPY MRPGLDEPAM AALEAEALRQ ARAAFETRPH DIACFVAEPI
     QGEGGDRHFR PEFFAAMREL CDEFDALLIF DEVQTGCGLT GTAWAYQQLD VAPDIVAFGK
     KTQVCGVMAG RRVDEVADNV FAVPSRLNST WGGNLTDMVR ARRILEVIEA EGLFERAVQH
     GKYLRARLDE LAADFPAVVL DPRGRGLMCA FSLPTTADRD ELIRQLWQRA VIVLPAGADT
     VRFRPPLTVS TAEIDAAIAA VRSALPVVT