ARCR_STAEQ
ID ARCR_STAEQ Reviewed; 228 AA.
AC Q5HKU6;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=HTH-type transcriptional regulator ArcR;
GN Name=arcR; OrderedLocusNames=SERP2246;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC under anaerobic conditions, thus playing an essential role in arginine
CC catabolism. May also control the expression of genes encoding proteins
CC which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; CP000029; AAW53105.1; -; Genomic_DNA.
DR RefSeq; WP_002486086.1; NC_002976.3.
DR AlphaFoldDB; Q5HKU6; -.
DR SMR; Q5HKU6; -.
DR STRING; 176279.SERP2246; -.
DR EnsemblBacteria; AAW53105; AAW53105; SERP2246.
DR KEGG; ser:SERP2246; -.
DR eggNOG; COG0664; Bacteria.
DR HOGENOM; CLU_1160528_0_0_9; -.
DR OMA; EYLCKNH; -.
DR OrthoDB; 1596937at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR012318; HTH_CRP.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF13545; HTH_Crp_2; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
PE 3: Inferred from homology;
KW Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..228
FT /note="HTH-type transcriptional regulator ArcR"
FT /id="PRO_0000349419"
FT DOMAIN 155..228
FT /note="HTH crp-type"
FT DNA_BIND 188..207
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT BINDING 22..141
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
SQ SEQUENCE 228 AA; 26896 MW; 07371F0A85C1D475 CRC64;
MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY YSSDETTHIY
LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP NEMCTALTDC EMIGIPRDLI
EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM ALTSKLAKER VTKILRYLCQ TVGYDHDEFY
EIKHFMTIQL LSDMAGISRE TTSHIINELK EEKILFKNSK NWLVSKDL
