ARCR_STAES
ID ARCR_STAES Reviewed; 228 AA.
AC Q8CML2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=HTH-type transcriptional regulator ArcR;
GN Name=arcR; OrderedLocusNames=SE_2214;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC under anaerobic conditions, thus playing an essential role in arginine
CC catabolism. May also control the expression of genes encoding proteins
CC which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AE015929; AAO05856.1; -; Genomic_DNA.
DR RefSeq; NP_765769.1; NC_004461.1.
DR RefSeq; WP_001831835.1; NZ_WBME01000025.1.
DR AlphaFoldDB; Q8CML2; -.
DR SMR; Q8CML2; -.
DR STRING; 176280.SE_2214; -.
DR DNASU; 1056495; -.
DR EnsemblBacteria; AAO05856; AAO05856; SE_2214.
DR GeneID; 50017717; -.
DR KEGG; sep:SE_2214; -.
DR PATRIC; fig|176280.10.peg.2161; -.
DR eggNOG; COG0664; Bacteria.
DR HOGENOM; CLU_1160528_0_0_9; -.
DR OMA; EYLCKNH; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR012318; HTH_CRP.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF13545; HTH_Crp_2; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
PE 3: Inferred from homology;
KW Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW Transcription; Transcription regulation.
FT CHAIN 1..228
FT /note="HTH-type transcriptional regulator ArcR"
FT /id="PRO_0000349418"
FT DOMAIN 155..228
FT /note="HTH crp-type"
FT DNA_BIND 188..207
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT BINDING 22..141
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
SQ SEQUENCE 228 AA; 26924 MW; 07370DBD75C1D475 CRC64;
MTGNQMFCRE NELDESFKQL ASYINIPVGV LLPFKSQCFV RHYNKGQIVY YSSDETTHIY
LLLKGNIMRE NFNLNGDVYR YLNREKVLFP LNNLFQDKVP NEMCTALTDC EMIGIPRDLI
EYLCKNHEEI FVKLFSLLSE TQCQHIEYNM ALTSKLAKER VTKILRYLCQ TVGYDHDEFY
EIKHFMTIQL LSDMAGISRE TTSHIINELR EEKILFKNSK NWLVSKDL