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LAX3_MEDTR
ID   LAX3_MEDTR              Reviewed;         465 AA.
AC   Q9FEL6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Auxin transporter-like protein 3;
DE   AltName: Full=AUX1-like protein 3;
DE   AltName: Full=MtLAX3;
GN   Name=LAX3;
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3880;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   STRAIN=cv. Jemalong; TISSUE=Root;
RX   PubMed=11277424; DOI=10.1094/mpmi.2001.14.3.267;
RA   de Billy F., Grosjean C., May S., Bennett M.J., Cullimore J.V.;
RT   "Expression studies on AUX1-like genes in Medicago truncatula suggest that
RT   auxin is required at two steps in early nodule development.";
RL   Mol. Plant Microbe Interact. 14:267-277(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, AND TISSUE SPECIFICITY.
RX   PubMed=15375694; DOI=10.1007/s00438-004-1057-x;
RA   Schnabel E.L., Frugoli J.;
RT   "The PIN and LAX families of auxin transport genes in Medicago
RT   truncatula.";
RL   Mol. Genet. Genomics 272:420-432(2004).
CC   -!- FUNCTION: Carrier protein involved in proton-driven auxin influx.
CC       Mediates the formation of auxin gradient from developing leaves (site
CC       of auxin biosynthesis) to tips by contributing to the loading of auxin
CC       in vascular tissues and facilitating acropetal (base to tip) auxin
CC       transport within inner tissues of the root apex, and basipetal (tip to
CC       base) auxin transport within outer tissues of the root apex (By
CC       similarity). May be involved in lateral roots and nodules formation.
CC       {ECO:0000250, ECO:0000269|PubMed:11277424}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Shoots and roots of nodulating plants. Low levels
CC       in roots, nodules, stems, petioles, leaves, shoot apices and flowers.
CC       {ECO:0000269|PubMed:11277424, ECO:0000269|PubMed:15375694}.
CC   -!- DEVELOPMENTAL STAGE: In primary roots, mostly localized in tips and to
CC       a lower extent in vasculature of older regions. In root tips, mostly
CC       expressed in the central tissues of the elongating zone (developing
CC       vasculature), in the starch-filled cells of the root cap and in some
CC       cortical cells. During lateral root development, striking expression in
CC       the proximal region of the primordium, close to the primary root
CC       central cylinder, and then in elongating cells of the developing
CC       vasculature and in developing root cap. During nodule formation,
CC       expressed in young elongated primordium, mostly in cells close to the
CC       root vasculature. In later stages, confined in small cells rich in
CC       amyloplasts with small nuclei. Near the periphery of developing nodules
CC       strong expression at the base that tapers off toward the apex. Not
CC       expressed in mature nodules. {ECO:0000269|PubMed:11277424}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       Amino acid/auxin permease (AAAP) (TC 2.A.18.1) subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Because of the similarity in sequence, the probe used to
CC       describe the developmental stages did not discriminate among the
CC       various MtLAX mRNAs. {ECO:0000305}.
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DR   EMBL; AJ299399; CAC12997.1; -; mRNA.
DR   EMBL; AY115842; AAM55303.1; -; Genomic_DNA.
DR   RefSeq; XP_003601086.1; XM_003601038.2.
DR   AlphaFoldDB; Q9FEL6; -.
DR   SMR; Q9FEL6; -.
DR   STRING; 3880.AES71337; -.
DR   EnsemblPlants; AES71337; AES71337; MTR_3g072870.
DR   GeneID; 11411395; -.
DR   Gramene; AES71337; AES71337; MTR_3g072870.
DR   eggNOG; KOG1303; Eukaryota.
DR   HOGENOM; CLU_027994_2_0_1; -.
DR   OMA; IRVHETK; -.
DR   OrthoDB; 509343at2759; -.
DR   ExpressionAtlas; Q9FEL6; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Auxin signaling pathway; Cell membrane; Membrane;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..465
FT                   /note="Auxin transporter-like protein 3"
FT                   /id="PRO_0000093847"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..72
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..129
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..165
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..189
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..225
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..259
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..307
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..349
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        371..374
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        396..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        443..465
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  52597 MW;  D20E5C8AA0B20593 CRC64;
     MTSEKVETVV AGNYLEMERE EEGSKSTTGK LSKFFWHGGS VYDAWFSCAS NQVAQVLLTL
     PYSFSQLGML SGILFQIFYG LMGSWTAYII SVLYVEYRTR KEREKVDFRN HVIQWFEVLD
     GLLGKHWRNL GLFFNCTFLL FGSVIQLIAC ASNIYYINDH LDKRTWTYIF GACCATTVFI
     PSFHNYRIWS FLGLVMTTYT AWYMTIASIL HGQAEDVKHS GPTKLVLYFT GATNILYTFG
     GHAVTVEIMH AMWKPQKFKM IYLIATLYVM TLTLPSAAAV YWAFGDNLLT HSNALSLLPR
     TGFRDTAVIL MLIHQFITFG FACTPLYFVW EKFLGVHETK SLLKRALVRL PVVIPIWFLA
     IIFPFFGPIN STVGSLLVSF TVYIIPALAH MVTFASAPAR ENAVERPPSF LGGWVGLYSV
     NVFVAVWVLV VGFGLGGWAS MLNFVHQIKT FGLFAKCFQC PPHKA
 
 
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