ID   ARCR_STAHJ              Reviewed;         227 AA.
AC   Q4L9J7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=HTH-type transcriptional regulator ArcR;
GN   Name=arcR; OrderedLocusNames=SH0369;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Positively regulates the expression of the arcABDCR operon
CC       under anaerobic conditions, thus playing an essential role in arginine
CC       catabolism. May also control the expression of genes encoding proteins
CC       which are involved in anaerobic metabolism. Can bind cyclic AMP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AP006716; BAE03678.1; -; Genomic_DNA.
DR   RefSeq; WP_011274695.1; NC_007168.1.
DR   AlphaFoldDB; Q4L9J7; -.
DR   SMR; Q4L9J7; -.
DR   STRING; 279808.SH0369; -.
DR   EnsemblBacteria; BAE03678; BAE03678; SH0369.
DR   KEGG; sha:SH0369; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_1160528_0_0_9; -.
DR   OMA; EYLCKNH; -.
DR   OrthoDB; 1596937at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   3: Inferred from homology;
KW   Activator; cAMP; cAMP-binding; Cytoplasm; DNA-binding; Nucleotide-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..227
FT                   /note="HTH-type transcriptional regulator ArcR"
FT                   /id="PRO_0000349420"
FT   DOMAIN          156..227
FT                   /note="HTH crp-type"
FT   DNA_BIND        189..208
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         41..130
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   227 AA;  26542 MW;  45851C0B0FDC1052 CRC64;
     MAGKTYINNR DNDLSEGLKQ LASYLNIPTG VIQAFKSECF VRRYNKGQII YYSSDQPTYV
     YLLLDGIVLR ETINEDGDAY RKLNKEQLLF PLNHLFRKIE LNEMCTAITP CNVIGIPKDM
     LEYLCKNHDD IFVTLFEKLN NELELLMEYN MALTTKLARE RIEKVLYYLC HAIGYDQDEF
     YEIKHIMTIQ LLSDLAGISR ETTGHIVHEL KEEKKLIKNG KNWMVIK