LAZH1_ARATH
ID LAZH1_ARATH Reviewed; 484 AA.
AC Q94CA0; O80656;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Protein LAZ1 homolog 1 {ECO:0000303|PubMed:20830211};
DE AltName: Full=Lazarus1 homolog 1 {ECO:0000303|PubMed:20830211};
DE Flags: Precursor;
GN OrderedLocusNames=At1g77220 {ECO:0000312|Araport:AT1G77220};
GN ORFNames=T14N5.8 {ECO:0000312|EMBL:AAC34348.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAK59540.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=20830211; DOI=10.1371/journal.pone.0012586;
RA Malinovsky F.G., Brodersen P., Fiil B.K., McKinney L.V., Thorgrimsen S.,
RA Beck M., Nielsen H.B., Pietra S., Zipfel C., Robatzek S., Petersen M.,
RA Hofius D., Mundy J.;
RT "Lazarus1, a DUF300 protein, contributes to programmed cell death
RT associated with Arabidopsis acd11 and the hypersensitive response.";
RL PLoS ONE 5:E12586-E12586(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC34348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004260; AAC34348.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35951.1; -; Genomic_DNA.
DR EMBL; AY035035; AAK59540.1; -; mRNA.
DR EMBL; AY113856; AAM44904.1; -; mRNA.
DR PIR; T00451; T00451.
DR RefSeq; NP_565152.1; NM_106371.3.
DR AlphaFoldDB; Q94CA0; -.
DR STRING; 3702.AT1G77220.1; -.
DR PaxDb; Q94CA0; -.
DR PRIDE; Q94CA0; -.
DR ProteomicsDB; 238408; -.
DR EnsemblPlants; AT1G77220.1; AT1G77220.1; AT1G77220.
DR GeneID; 844058; -.
DR Gramene; AT1G77220.1; AT1G77220.1; AT1G77220.
DR KEGG; ath:AT1G77220; -.
DR Araport; AT1G77220; -.
DR TAIR; locus:2196005; AT1G77220.
DR eggNOG; KOG2641; Eukaryota.
DR HOGENOM; CLU_012923_0_1_1; -.
DR InParanoid; Q94CA0; -.
DR OrthoDB; 462913at2759; -.
DR PhylomeDB; Q94CA0; -.
DR PRO; PR:Q94CA0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94CA0; baseline and differential.
DR Genevisible; Q94CA0; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
DR GO; GO:1900458; P:negative regulation of brassinosteroid mediated signaling pathway; IGI:TAIR.
DR GO; GO:0007033; P:vacuole organization; IGI:TAIR.
DR GO; GO:0098876; P:vesicle-mediated transport to the plasma membrane; IGI:TAIR.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..484
FT /note="Protein LAZ1 homolog 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000432838"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 406..428
FT /evidence="ECO:0000255"
FT COMPBIAS 459..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 55378 MW; F646EA4719D64BF4 CRC64;
MEWRGILCSL LFIVSVGESS SRFGIMWHPN LGVDSGQYLT WPILSASVFV VIAILLPMYL
IFEHLASYNQ PEEQKFLIGL ILMVPVYAVE SFLSLVNSEA AFNCEVIRDC YEAFALYCFE
RYLIACLDGE ERTIEFMEQQ TVITQSTPLL EGTCSYGVVE HPFPMNCFVK DWSLGPQFYH
AVKIGIVQYM ILKMICALLA MILEAFGVYG EGKFAWNYGY PYLAVVLNFS QTWALYCLVQ
FYNVIKDKLA PIKPLAKFLT FKSIVFLTWW QGIIVAFLFS MGLVKGSLAK ELKTRIQDYI
ICIEMGIAAV VHLYVFPAAP YKRGERCVRN VAVMSDYASI DVPPDPEEVK DSERTTRTRY
GRHDDREKRL NFPQSVRDVV LGSGEIIVDD MRFTVSHVVE PVERGIAKIN RTFHQISENV
KRFEQQKKTT KDDSYVIPLN QWAKEFSDVH ENLYDGGSVS DSGLGSTNRH HQSRVSGLWT
RMRR
