LAZH2_ARATH
ID LAZH2_ARATH Reviewed; 403 AA.
AC Q5BPZ5; O49309;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Protein LAZ1 homolog 2 {ECO:0000303|PubMed:20830211};
DE AltName: Full=Lazarus1 homolog 2 {ECO:0000303|PubMed:20830211};
GN OrderedLocusNames=At1g23070 {ECO:0000312|Araport:AT1G23070};
GN ORFNames=T26J12.15 {ECO:0000312|EMBL:AAC00612.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAX23758.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Xiao Y., Underwood B.A., Moskal W., Redman J., Wang W., Monaghan E.,
RA Wu H.C., Utterback T., Town C.D.;
RT "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT thaliana from 5' and 3' RACE products.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=20830211; DOI=10.1371/journal.pone.0012586;
RA Malinovsky F.G., Brodersen P., Fiil B.K., McKinney L.V., Thorgrimsen S.,
RA Beck M., Nielsen H.B., Pietra S., Zipfel C., Robatzek S., Petersen M.,
RA Hofius D., Mundy J.;
RT "Lazarus1, a DUF300 protein, contributes to programmed cell death
RT associated with Arabidopsis acd11 and the hypersensitive response.";
RL PLoS ONE 5:E12586-E12586(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=Q5BPZ5-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC00612.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002311; AAC00612.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30330.1; -; Genomic_DNA.
DR EMBL; AY924683; AAX23758.1; -; mRNA.
DR EMBL; DQ132657; AAZ52687.1; -; mRNA.
DR PIR; H86364; H86364.
DR RefSeq; NP_173720.3; NM_102155.3. [Q5BPZ5-1]
DR AlphaFoldDB; Q5BPZ5; -.
DR STRING; 3702.AT1G23070.1; -.
DR PaxDb; Q5BPZ5; -.
DR PRIDE; Q5BPZ5; -.
DR ProteomicsDB; 237072; -. [Q5BPZ5-1]
DR EnsemblPlants; AT1G23070.1; AT1G23070.1; AT1G23070. [Q5BPZ5-1]
DR GeneID; 838915; -.
DR Gramene; AT1G23070.1; AT1G23070.1; AT1G23070. [Q5BPZ5-1]
DR KEGG; ath:AT1G23070; -.
DR Araport; AT1G23070; -.
DR TAIR; locus:2201235; AT1G23070.
DR eggNOG; KOG2641; Eukaryota.
DR HOGENOM; CLU_012923_0_2_1; -.
DR InParanoid; Q5BPZ5; -.
DR OMA; QKWIVAV; -.
DR OrthoDB; 462913at2759; -.
DR PhylomeDB; Q5BPZ5; -.
DR PRO; PR:Q5BPZ5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q5BPZ5; baseline and differential.
DR Genevisible; Q5BPZ5; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..403
FT /note="Protein LAZ1 homolog 2"
FT /id="PRO_0000432839"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45537 MW; 9536A56673AC6638 CRC64;
MGVTETSTYR DLHLPSLIIG GSFATVAICL SLYSILQHLR FYTNPAEQKW IVSVLFMVPV
YATESIISLS NSKFSLPCDI LRNCYEAFAL YSFGSYLVAC LGGERRVVEY LENESKKPLL
EEGANESKKK KKKNSFWKFL CDPYVLGREL FVIEKFGLVQ YMILKTFCAF LTFLLELLGV
YGDGEFKWYY GYPYIVVVLN FSQMWALFCL VQFYNVTHER LKEIKPLAKF ISFKAIVFAT
WWQGFGIALL CYYGILPKEG RFQNGLQDFL ICIEMAIAAV AHLFVFPAEP YHYIPVSECG
KITAETSKTE VKLEEGGLVE TTETQVEASG TSIKESVQDI VIDGGQHVVK DVVLTINQAI
GPVEKGVTKI QDTIHQKLLD SDGKEETEVT EEVTVETSVP PKE
