LAZY1_MAIZE
ID LAZY1_MAIZE Reviewed; 413 AA.
AC B4FG96; G3LSI0;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Protein LAZY 1 {ECO:0000305};
DE Short=ZmLA1 {ECO:0000303|PubMed:24089437};
DE AltName: Full=Protein CONTROLLING LEAF ANGLE 4 {ECO:0000305};
DE Short=ZmCLA4 {ECO:0000303|PubMed:24987012};
DE AltName: Full=Protein PROSTRATE STEM 1 {ECO:0000303|PubMed:24089437};
GN Name=LA1 {ECO:0000305};
GN Synonyms=CLA4 {ECO:0000303|PubMed:24987012},
GN PS1 {ECO:0000303|PubMed:24089437};
GN ORFNames=ZEAMMB73_681845 {ECO:0000312|EMBL:AFW60749.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC TISSUE=Leaf;
RX PubMed=24987012; DOI=10.1093/jxb/eru271;
RA Zhang J., Ku L.X., Han Z.P., Guo S.L., Liu H.J., Zhang Z.Z., Cao L.R.,
RA Cui X.J., Chen Y.H.;
RT "The ZmCLA4 gene in the qLA4-1 QTL controls leaf angle in maize (Zea mays
RT L.).";
RL J. Exp. Bot. 65:5063-5076(2014).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, AND NUCLEAR
RP LOCALIZATION SIGNAL.
RX PubMed=24089437; DOI=10.1104/pp.113.227314;
RA Dong Z., Jiang C., Chen X., Zhang T., Ding L., Song W., Luo H., Lai J.,
RA Chen H., Liu R., Zhang X., Jin W.;
RT "Maize LAZY1 mediates shoot gravitropism and inflorescence development
RT through regulating auxin transport, auxin signaling, and light response.";
RL Plant Physiol. 163:1306-1322(2013).
CC -!- FUNCTION: Involved in the regulation of shoot gravitropism, and tassel
CC and ear development through the regulation of polar auxin transport
CC (PAT) and auxin signaling. Acts as negative regulator of basipetal PAT,
CC but positive regulator of lateral auxin transport (PubMed:24089437).
CC Involved in the regulation of shoot gravitropism and leaf angle through
CC the regulation of cell development (PubMed:24987012).
CC {ECO:0000269|PubMed:24089437, ECO:0000269|PubMed:24987012}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24089437,
CC ECO:0000269|PubMed:24987012}; Single-pass membrane protein
CC {ECO:0000255}. Nucleus {ECO:0000269|PubMed:24089437,
CC ECO:0000269|PubMed:24987012}.
CC -!- TISSUE SPECIFICITY: Expressed in the node of the stem, initiating leaf
CC founder cells, young leaf primordia, tips of axillary meristems,
CC spikelet pair meristems of developing tassels and ears, male flower
CC primordia, tassels, ears, silks and seeds (PubMed:24089437). Expressed
CC in leaf sheaths, leaf pulvinus and shoot apical meristem (SAM)
CC (PubMed:24987012). {ECO:0000269|PubMed:24089437,
CC ECO:0000269|PubMed:24987012}.
CC -!- INDUCTION: Transiently down-regulated by auxin. Down-regulated by
CC light. {ECO:0000269|PubMed:24089437}.
CC -!- DISRUPTION PHENOTYPE: Reduced shoot gravitropism and defective
CC inflorescence development (PubMed:24089437). Reduced shoot gravitropism
CC and increased leaf angle (PubMed:24987012).
CC {ECO:0000269|PubMed:24089437, ECO:0000269|PubMed:24987012}.
CC -!- SIMILARITY: Belongs to the LAZY family. {ECO:0000305}.
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DR EMBL; JN409349; AEM59513.1; -; mRNA.
DR EMBL; CM000780; AFW60749.1; -; Genomic_DNA.
DR EMBL; BT036134; ACF81139.1; -; mRNA.
DR EMBL; BT055693; ACL54300.1; -; mRNA.
DR RefSeq; NP_001132334.1; NM_001138862.1.
DR AlphaFoldDB; B4FG96; -.
DR STRING; 4577.GRMZM2G135019_P01; -.
DR PaxDb; B4FG96; -.
DR PRIDE; B4FG96; -.
DR EnsemblPlants; Zm00001eb169480_T001; Zm00001eb169480_P001; Zm00001eb169480.
DR GeneID; 100193776; -.
DR Gramene; Zm00001eb169480_T001; Zm00001eb169480_P001; Zm00001eb169480.
DR KEGG; zma:100193776; -.
DR eggNOG; ENOG502QRWV; Eukaryota.
DR HOGENOM; CLU_061468_0_0_1; -.
DR OMA; FRQNSNE; -.
DR OrthoDB; 1304166at2759; -.
DR Proteomes; UP000007305; Chromosome 4.
DR ExpressionAtlas; B4FG96; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0009630; P:gravitropism; IEA:InterPro.
DR GO; GO:2000012; P:regulation of auxin polar transport; IMP:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR038928; LAZY1.
DR PANTHER; PTHR34959; PTHR34959; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Growth regulation; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..413
FT /note="Protein LAZY 1"
FT /id="PRO_0000437474"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 103..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 275..298
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000269|PubMed:24089437"
FT MOTIF 338..345
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000269|PubMed:24089437"
FT COMPBIAS 103..122
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 26
FT /note="A -> G (in Ref. 1; AEM59513)"
FT /evidence="ECO:0000305"
FT CONFLICT 140..144
FT /note="IEDAT -> VEDVA (in Ref. 1; AEM59513)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="G -> GG (in Ref. 1; AEM59513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 413 AA; 43615 MW; EA9C9E1EF8D67800 CRC64;
MKLLGWMHRK LRQNSNDVFK EFNNAAGGTC NCITGLAASD PATFLATANE YFTADNDFTN
NHPSSPAADL FTFGGSGLLT IGTLGIAAVA VSADADEVDY DVDADADSDF DDNDDTAGDD
EDQVDSAVTP TFTYAAPPPI EDATVVEKAA VAVVEAIAEK DDDTTTEDDL MVVSAELEKV
LGGRNSGTAG DLVASARVSF AMGVDCPLQG FLFGSPVSDA ESRLEQPRDS NGGRRTSLGE
LFMRTRFAEE KVALVAVEEG EDGGDIGAGG ERDDRKAGKG GGGHKTTKKR SAKDEKVPRG
DGAQASATVT KSKFHKILQI FHRKVYPESA ALARNLTKKS RKRGSGAYHK PEPAASKLRC
LKEQRAPGFG CCASRASFGG AASPIDGDDD DELNGSKSGH WIKTDAEYLV LEL
