LAZY1_ORYSJ
ID LAZY1_ORYSJ Reviewed; 416 AA.
AC Q2R435;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein LAZY 1 {ECO:0000303|PubMed:17468779};
GN Name=LA1 {ECO:0000303|PubMed:17468779};
GN Synonyms=LA {ECO:0000312|EMBL:ABI34464.1};
GN OrderedLocusNames=Os11g0490600 {ECO:0000312|EMBL:BAF28289.1},
GN LOC_Os11g29840 {ECO:0000312|EMBL:ABA93814.2};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=17468779; DOI=10.1038/cr.2007.38;
RA Li P., Wang Y., Qian Q., Fu Z., Wang M., Zeng D., Li B., Wang X., Li J.;
RT "LAZY1 controls rice shoot gravitropism through regulating polar auxin
RT transport.";
RL Cell Res. 17:402-410(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Shiokari;
RX PubMed=17412736; DOI=10.1093/pcp/pcm042;
RA Yoshihara T., Iino M.;
RT "Identification of the gravitropism-related rice gene LAZY1 and elucidation
RT of LAZY1-dependent and -independent gravity signaling pathways.";
RL Plant Cell Physiol. 48:678-688(2007).
RN [8]
RP FUNCTION.
RX PubMed=17908158; DOI=10.1111/j.1365-313x.2007.03284.x;
RA Yu B., Lin Z., Li H., Li X., Li J., Wang Y., Zhang X., Zhu Z., Zhai W.,
RA Wang X., Xie D., Sun C.;
RT "TAC1, a major quantitative trait locus controlling tiller angle in rice.";
RL Plant J. 52:891-898(2007).
RN [9]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25028496; DOI=10.1073/pnas.1411859111;
RA Sang D., Chen D., Liu G., Liang Y., Huang L., Meng X., Chu J., Sun X.,
RA Dong G., Yuan Y., Qian Q., Li J., Wang Y.;
RT "Strigolactones regulate rice tiller angle by attenuating shoot
RT gravitropism through inhibiting auxin biosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:11199-11204(2014).
CC -!- FUNCTION: Involved in the regulation of shoot gravitropism and tiller
CC angle through negative regulation of basipetal polar auxin transport
CC (PAT) (PubMed:17468779, PubMed:17412736, PubMed:25028496). Acts as
CC positive regulator of lateral auxin transport (PubMed:17468779,
CC PubMed:25028496, PubMed:17412736). Promotes vertical shoot growth
CC (PubMed:17908158). LAZY1 and TAC1 play opposite functions in the
CC regulation of tiller growth angle (PubMed:17908158).
CC {ECO:0000269|PubMed:17412736, ECO:0000269|PubMed:17468779,
CC ECO:0000269|PubMed:17908158, ECO:0000269|PubMed:25028496}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17468779};
CC Single-pass membrane protein {ECO:0000255}. Nucleus
CC {ECO:0000269|PubMed:17468779}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in the cells at the inner
CC side of the vascular bundles of young leaf sheaths and peripheral
CC cylinders of vascular bundles in the unelongated stems
CC (PubMed:17468779). Expressed in the leaf sheath pulvinus and the lamina
CC joint (PubMed:17412736). {ECO:0000269|PubMed:17412736,
CC ECO:0000269|PubMed:17468779}.
CC -!- DISRUPTION PHENOTYPE: Tiller-spreading phenotype due to defective shoot
CC and tiller gravitropism. Extremely larger leaf angle at reproductive
CC stage. Altered endogenous auxin distribution in shoots.
CC {ECO:0000269|PubMed:17412736, ECO:0000269|PubMed:17468779,
CC ECO:0000269|PubMed:25028496}.
CC -!- SIMILARITY: Belongs to the LAZY family. {ECO:0000305}.
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DR EMBL; DQ855268; ABI34464.1; -; Genomic_DNA.
DR EMBL; DP000010; ABA93814.2; -; Genomic_DNA.
DR EMBL; AP008217; BAF28289.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT14087.1; -; Genomic_DNA.
DR EMBL; AK067664; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015616691.1; XM_015761205.1.
DR AlphaFoldDB; Q2R435; -.
DR SMR; Q2R435; -.
DR STRING; 4530.OS11T0490600-01; -.
DR PaxDb; Q2R435; -.
DR PRIDE; Q2R435; -.
DR EnsemblPlants; Os11t0490600-01; Os11t0490600-01; Os11g0490600.
DR GeneID; 4350543; -.
DR Gramene; Os11t0490600-01; Os11t0490600-01; Os11g0490600.
DR KEGG; osa:4350543; -.
DR eggNOG; ENOG502QRWV; Eukaryota.
DR HOGENOM; CLU_061468_0_0_1; -.
DR InParanoid; Q2R435; -.
DR OMA; FRQNSNE; -.
DR OrthoDB; 1304166at2759; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR ExpressionAtlas; Q2R435; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0009630; P:gravitropism; IEA:InterPro.
DR GO; GO:2000012; P:regulation of auxin polar transport; IMP:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR038928; LAZY1.
DR PANTHER; PTHR34959; PTHR34959; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Growth regulation; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..416
FT /note="Protein LAZY 1"
FT /id="PRO_0000437473"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 266..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 69..75
FT /note="IGT motif"
FT /evidence="ECO:0000305"
FT MOTIF 278..295
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 416 AA; 42667 MW; 4AA326FA165F72FC CRC64;
MKLLGWMHRK LRSNNDVFKE FNTGGGGACN CITGLASPDH DNDYFSGDDA AHASPPVTAG
DLFTFGGSGL LTIGTLGIAA VAIPSGGDDD DYDIDFEVDA TSDDDGGFTV EDDDADVGGA
VTPTFTFPAA TAAEAVVATV EKAVAAVEAI AEKDDDTTTE DDLMVVSAEL EKVLGGVDVA
SARVSFAMGG GVDCPLQGFL FGSPVSDVES RPEYLQAPRD SSGSCGGGGR RTSLGELFMR
TRFADEKVAL VAVAEGEDGV AGDDGAAAAG VGGDRAGKGG GYKTMKKRKV KDEKGGGGAA
GGGMPATVTK SKFQKILQIF HRKVYPENTL LTRNLTKKSR NRGATDNGGG AVATGDPDGP
LASPVLRCRK DHPMRGFGCC TNGAFGASSP GGNAEMNGNK SGHWIKTDAD YLVLEL
