LAZY2_ARATH
ID LAZY2_ARATH Reviewed; 295 AA.
AC Q58G53; A0A178WAB6; Q9LNR9; Q9LQJ1;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Protein LAZY 2 {ECO:0000303|PubMed:28821594};
DE Short=AtLAZY2 {ECO:0000303|PubMed:28821594};
DE AltName: Full=Protein DEEPER ROOTING 3 {ECO:0000305};
DE Short=AtDRO3 {ECO:0000305};
DE AltName: Full=Protein LAZY1-LIKE 2 {ECO:0000303|PubMed:28765510};
DE AltName: Full=Protein NEGATIVE GRAVITROPIC RESPONSE OF ROOTS 1 {ECO:0000303|PubMed:27748769};
DE Short=AtNGR1 {ECO:0000303|PubMed:27748769};
GN Name=LAZY2 {ECO:0000303|PubMed:28821594};
GN Synonyms=DRO3 {ECO:0000305}, LZY2 {ECO:0000303|PubMed:28765510},
GN NGR1 {ECO:0000303|PubMed:27748769};
GN OrderedLocusNames=At1g17400 {ECO:0000312|Araport:AT1G17400};
GN ORFNames=F1L3.5 {ECO:0000312|EMBL:AAF79489.1},
GN F28G4.14 {ECO:0000312|EMBL:AAF97317.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27748769; DOI=10.1038/nplants.2016.155;
RA Ge L., Chen R.;
RT "Negative gravitropism in plant roots.";
RL Nat. Plants 2:16155-16155(2016).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=28765510; DOI=10.1105/tpc.16.00575;
RA Taniguchi M., Furutani M., Nishimura T., Nakamura M., Fushita T.,
RA Iijima K., Baba K., Tanaka H., Toyota M., Tasaka M., Morita M.T.;
RT "The Arabidopsis LAZY1 family plays a key role in gravity signaling within
RT statocytes and in branch angle control of roots and shoots.";
RL Plant Cell 29:1984-1999(2017).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=28821594; DOI=10.1104/pp.17.00942;
RA Yoshihara T., Spalding E.P.;
RT "LAZY genes mediate the effects of gravity on auxin gradients and plant
RT architecture.";
RL Plant Physiol. 175:959-969(2017).
CC -!- FUNCTION: Involved in the regulation of root gravitropism
CC (PubMed:27748769). Functions redundantly with LAZY3 and LAZY4 in the
CC control of root gravitropism (PubMed:27748769). Functions redundantly
CC with LAZY1, LAZY3 and LAZY4 to control plant architecture by coupling
CC gravity sensing to the formation of auxin gradients (PubMed:28821594).
CC Involved redundantly with LAZY1 and LAZY4 in the regulation of both
CC shoot and root gravitropism (PubMed:28765510). Mediates gravity
CC signaling in statocytes downstream of amyloplast displacement, leading
CC to the generation of asymmetric auxin distribution in gravity-
CC responding organs (PubMed:28765510). Regulates the direction of polar
CC auxin transport in response to gravity through the control of
CC asymmetric PIN3 expression in the root cap columella (PubMed:28765510).
CC Regulation of auxin flow by the three proteins LAZY1, LAZY2 and LAZY4
CC in statocytes influences plant architecture by controlling the growth
CC angle of lateral shoots and lateral roots (PubMed:28765510).
CC {ECO:0000269|PubMed:27748769, ECO:0000269|PubMed:28765510,
CC ECO:0000269|PubMed:28821594}.
CC -!- TISSUE SPECIFICITY: Expressed in the endodermis of inflorescence stems
CC and hypocotyls (PubMed:28765510). Highly expressed in hypocotyls and
CC root tips of young seedlings (PubMed:28821594).
CC {ECO:0000269|PubMed:28765510, ECO:0000269|PubMed:28821594}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions (PubMed:27748769). Roots of plants lacking LAZY2, LAZY3 and
CC LAZY4 exhibit a negative gravitropic response, and grow upward in the
CC opposite direrction of root gravitropism (PubMed:27748769).
CC {ECO:0000269|PubMed:27748769}.
CC -!- SIMILARITY: Belongs to the LAZY family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79489.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF97317.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; KT021796; ANJ86423.1; -; mRNA.
DR EMBL; AC007843; AAF97317.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC022492; AAF79489.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29582.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59391.1; -; Genomic_DNA.
DR EMBL; AY954756; AAX55082.1; -; mRNA.
DR RefSeq; NP_001321754.1; NM_001332302.1.
DR RefSeq; NP_173183.3; NM_101601.4.
DR AlphaFoldDB; Q58G53; -.
DR STRING; 3702.AT1G17400.1; -.
DR PaxDb; Q58G53; -.
DR PRIDE; Q58G53; -.
DR EnsemblPlants; AT1G17400.1; AT1G17400.1; AT1G17400.
DR EnsemblPlants; AT1G17400.2; AT1G17400.2; AT1G17400.
DR GeneID; 838312; -.
DR Gramene; AT1G17400.1; AT1G17400.1; AT1G17400.
DR Gramene; AT1G17400.2; AT1G17400.2; AT1G17400.
DR KEGG; ath:AT1G17400; -.
DR Araport; AT1G17400; -.
DR TAIR; locus:2018821; AT1G17400.
DR eggNOG; ENOG502RRH5; Eukaryota.
DR HOGENOM; CLU_068790_0_0_1; -.
DR InParanoid; Q58G53; -.
DR OMA; DIRSICV; -.
DR OrthoDB; 1227635at2759; -.
DR PhylomeDB; Q58G53; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q58G53; baseline and differential.
DR GO; GO:0009630; P:gravitropism; IMP:TAIR.
DR GO; GO:0009958; P:positive gravitropism; IGI:TAIR.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR044683; LAZY.
DR PANTHER; PTHR34045; PTHR34045; 1.
PE 2: Evidence at transcript level;
KW Growth regulation; Reference proteome.
FT CHAIN 1..295
FT /note="Protein LAZY 2"
FT /id="PRO_0000451018"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 42..48
FT /note="IGT motif"
FT /evidence="ECO:0000305"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 33715 MW; 8FA2F0F2CAB2E364 CRC64;
MKFFGWMQNK LNGDHNRTST SSASSHHVKQ EPREEFSDWP HALLAIGTFG TTSNSVSENE
SKNVHEEIEA EKKCTAQSEQ EEEPSSSVNL EDFTPEEVGK LQKELMKLLS RTKKRKSDVN
RELMKNLPLD RFLNCPSSLE VDRRISNALS AVVDSSEENK EEDMERTINV ILGRCKEISI
ESKNNKKKRD ISKNSVSYLF KKIFVCADGI STAPSPSLRD TLQESRMEKL LKMMLHKKIN
AQASSKPTSL TTKRYLQDKK QLSLKSEEEE TSERRSSSDG YKWVKTDSDF IVLEI
