LAZY3_ARATH
ID LAZY3_ARATH Reviewed; 175 AA.
AC Q1G3U5; A0MDM5; Q9LMB6;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein LAZY 3 {ECO:0000303|PubMed:28821594};
DE Short=AtLAZY3 {ECO:0000303|PubMed:28821594};
DE AltName: Full=Protein DEEPER ROOTING 2 {ECO:0000303|PubMed:28029738};
DE Short=AtDRO2 {ECO:0000303|PubMed:28029738};
DE AltName: Full=Protein LAZY1-LIKE 4 {ECO:0000305};
DE AltName: Full=Protein NEGATIVE GRAVITROPIC RESPONSE OF ROOTS 3 {ECO:0000303|PubMed:27748769};
DE Short=AtNGR3 {ECO:0000303|PubMed:27748769};
GN Name=LAZY3 {ECO:0000303|PubMed:28821594};
GN Synonyms=DRO2 {ECO:0000303|PubMed:28029738}, LZY4 {ECO:0000305},
GN NGR3 {ECO:0000303|PubMed:27748769};
GN OrderedLocusNames=At1g19115 {ECO:0000312|Araport:AT1G19115};
GN ORFNames=F14D16.27 {ECO:0000312|EMBL:AAF79295.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27748769; DOI=10.1038/nplants.2016.155;
RA Ge L., Chen R.;
RT "Negative gravitropism in plant roots.";
RL Nat. Plants 2:16155-16155(2016).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=28029738; DOI=10.1111/tpj.13470;
RA Guseman J.M., Webb K., Srinivasan C., Dardick C.;
RT "DRO1 influences root system architecture in Arabidopsis and Prunus
RT species.";
RL Plant J. 89:1093-1105(2017).
RN [6]
RP FUNCTION.
RX PubMed=28821594; DOI=10.1104/pp.17.00942;
RA Yoshihara T., Spalding E.P.;
RT "LAZY genes mediate the effects of gravity on auxin gradients and plant
RT architecture.";
RL Plant Physiol. 175:959-969(2017).
CC -!- FUNCTION: Involved in the regulation of root gravitropism
CC (PubMed:27748769). Functions redundantly with LAZY2 and LAZY4 in the
CC control of root gravitropism (PubMed:27748769). Functions redundantly
CC with LAZY1, LAZY2 and LAZY4 to control plant architecture by coupling
CC gravity sensing to the formation of auxin gradients (PubMed:28821594).
CC {ECO:0000269|PubMed:27748769, ECO:0000269|PubMed:28821594}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in roots (PubMed:28029738).
CC Expressed in root tips of young seedlings (PubMed:28821594).
CC {ECO:0000269|PubMed:28029738, ECO:0000269|PubMed:28821594}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions (PubMed:27748769). Roots of plants lacking LAZY2, LAZY3 and
CC LAZY4 exhibit a negative gravitropic response, and grow upward in the
CC opposite direrction of root gravitropism (PubMed:27748769).
CC {ECO:0000269|PubMed:27748769}.
CC -!- SIMILARITY: Belongs to the LAZY family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79295.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABK28324.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KT021798; ANJ86425.1; -; mRNA.
DR EMBL; AC068602; AAF79295.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29806.1; -; Genomic_DNA.
DR EMBL; DQ487489; ABF59201.1; -; mRNA.
DR EMBL; DQ652641; ABK28324.1; ALT_SEQ; mRNA.
DR PIR; E86324; E86324.
DR RefSeq; NP_001117313.1; NM_001123841.4.
DR AlphaFoldDB; Q1G3U5; -.
DR STRING; 3702.AT1G19115.3; -.
DR PaxDb; Q1G3U5; -.
DR PRIDE; Q1G3U5; -.
DR EnsemblPlants; AT1G19115.3; AT1G19115.3; AT1G19115.
DR GeneID; 5007705; -.
DR Gramene; AT1G19115.3; AT1G19115.3; AT1G19115.
DR KEGG; ath:AT1G19115; -.
DR Araport; AT1G19115; -.
DR TAIR; locus:4010713453; AT1G19115.
DR HOGENOM; CLU_068790_0_0_1; -.
DR OMA; AKKWVNT; -.
DR PhylomeDB; Q1G3U5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1G3U5; baseline and differential.
DR GO; GO:0009630; P:gravitropism; IMP:TAIR.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR044683; LAZY.
DR PANTHER; PTHR34045; PTHR34045; 1.
PE 2: Evidence at transcript level;
KW Growth regulation; Reference proteome.
FT CHAIN 1..175
FT /note="Protein LAZY 3"
FT /id="PRO_0000451019"
FT REGION 9..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 44..50
FT /note="IGT motif"
FT /evidence="ECO:0000305"
FT COMPBIAS 17..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 60
FT /note="Missing (in Ref. 4; ABK28324)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 175 AA; 19828 MW; 808360B2D1296511 CRC64;
MKIFSWVQRK LSGKKRVPTS DSSQEPSSPP LSKEVQGLPQ DEETFLAIGT LGNNIFPKQE
EEEEETDSSK DITPVNTDVT IGKKKSLSFL LKKMFVCTSG FKTPPPLLDL SRGDSLHNTR
MEKMLRTILN KKIHPQRSNS IAKKYLESNH KIMDEARSSV DANKWVKTDS ECEIF
