ID   LA_AEDAL                Reviewed;         383 AA.
AC   Q26457;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=La protein homolog;
DE   AltName: Full=La autoantigen homolog;
DE   AltName: Full=La ribonucleoprotein;
OS   Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=8551578; DOI=10.1128/jvi.70.2.1173-1181.1996;
RA   Pardigon N., Strauss J.H.;
RT   "Mosquito homolog of the La autoantigen binds to Sindbis virus RNA.";
RL   J. Virol. 70:1173-1181(1996).
CC   -!- FUNCTION: May be involved in transcription termination by RNA
CC       polymerase III. Binds RNA and DNA. Binds to the 3' end of the minus
CC       strand of Sindbis virus RNA. This may be significant for Sindbis virus
CC       RNA replication.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Primarily nuclear, but
CC       significant amounts are present in the cytoplasm.
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DR   EMBL; S80954; AAB35931.1; -; mRNA.
DR   AlphaFoldDB; Q26457; -.
DR   SMR; Q26457; -.
DR   PRIDE; Q26457; -.
DR   VEuPathDB; VectorBase:AALC636_034625; -.
DR   VEuPathDB; VectorBase:AALF018320; -.
DR   VEuPathDB; VectorBase:AALFPA_080594; -.
DR   Proteomes; UP000069940; Genome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR045180; La_dom_prot.
DR   InterPro; IPR006630; La_HTH.
DR   InterPro; IPR014886; La_xRRM.
DR   InterPro; IPR002344; Lupus_La.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22792; PTHR22792; 1.
DR   Pfam; PF05383; La; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF08777; RRM_3; 1.
DR   PRINTS; PR00302; LUPUSLA.
DR   SMART; SM00715; LA; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50961; HTH_LA; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   PROSITE; PS51939; XRRM; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus; RNA-binding.
FT   CHAIN           1..383
FT                   /note="La protein homolog"
FT                   /id="PRO_0000207605"
FT   DOMAIN          37..129
FT                   /note="HTH La-type RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00332"
FT   DOMAIN          141..228
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          249..368
FT                   /note="xRRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01288"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  44430 MW;  4E5CC8F21C40F452 CRC64;
     MTEVEAKATA TEETTKEEEE APETTAEQTE ESAQETSENV SKLEASTIRQ LEYYFGDANL
     ARDKFLQEQI SKDEGWVPVD VLLTFKRLKS LSEDKKVIVD AIEKSDEGLI EVSEDREKLR
     RHPERPLPEQ NEETRKEIYG RTVYVKGFAP EEGTQMSELL EFFEPFEKIT NIVMRKYHDK
     ATKKYLFKGS VFVTFATKDH CAEFLKKEKL GYKGKELIRK MQDDYFEEKK AERRKKDKKK
     EEDRFNIDHL PKGASVHLSG FNKDTSRETI KETILKLDES LEVAFIDYAK TDTEGTVRFA
     ADDAGKKFME KLTDSKIQID EEEITARLLE GDEEKEFLRK VVKDQQARRQ ASNARNKGRT
     PEGRQASRPP QEWRRKAKGG RGE