ID   LBD12_ARATH             Reviewed;         193 AA.
AC   Q8LBW3; B7XG59; O64734; Q549W5;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2003, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=LOB domain-containing protein 12;
DE   AltName: Full=ASYMMETRIC LEAVES 2-like protein 5;
DE            Short=AS2-like protein 5;
GN   Name=LBD12; Synonyms=ASL5; OrderedLocusNames=At2g30130; ORFNames=T27E13.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12040093; DOI=10.1093/pcp/pcf077;
RA   Iwakawa H., Ueno Y., Semiarti E., Onouchi H., Kojima S., Tsukaya H.,
RA   Hasebe M., Soma T., Ikezaki M., Machida C., Machida Y.;
RT   "The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana, required for
RT   formation of a symmetric flat leaf lamina, encodes a member of a novel
RT   family of proteins characterized by cysteine repeats and a leucine
RT   zipper.";
RL   Plant Cell Physiol. 43:467-478(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=19154202; DOI=10.1111/j.1365-313x.2009.03797.x;
RA   Matsumura Y., Iwakawa H., Machida Y., Machida C.;
RT   "Characterization of genes in the ASYMMETRIC LEAVES2/LATERAL ORGAN
RT   BOUNDARIES (AS2/LOB) family in Arabidopsis thaliana, and functional and
RT   molecular comparisons between AS2 and other family members.";
RL   Plant J. 58:525-537(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12068116; DOI=10.1104/pp.010926;
RA   Shuai B., Reynaga-Pena C.G., Springer P.S.;
RT   "The LATERAL ORGAN BOUNDARIES gene defines a novel, plant-specific gene
RT   family.";
RL   Plant Physiol. 129:747-761(2002).
RN   [7]
RP   FUNCTION.
RX   PubMed=12787254; DOI=10.1046/j.1365-313x.2003.01758.x;
RA   Nakazawa M., Ichikawa T., Ishikawa A., Kobayashi H., Tsuhara Y.,
RA   Kawashima M., Suzuki K., Muto S., Matsui M.;
RT   "Activation tagging, a novel tool to dissect the functions of a gene
RT   family.";
RL   Plant J. 34:741-750(2003).
CC   -!- INTERACTION:
CC       Q8LBW3; A0A1P8AWD1: At1g04445; NbExp=3; IntAct=EBI-15198991, EBI-15193325;
CC       Q8LBW3; A0A178VFA3: At3g19070; NbExp=3; IntAct=EBI-15198991, EBI-15192431;
CC       Q8LBW3; F4K1A8: At5g26749; NbExp=3; IntAct=EBI-15198991, EBI-15191587;
CC       Q8LBW3; Q9AT61: LBD13; NbExp=3; IntAct=EBI-15198991, EBI-4432427;
CC       Q8LBW3; P59467: LBD23; NbExp=3; IntAct=EBI-15198991, EBI-15193845;
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in roots, and at low levels
CC       in shoots, floral stems and open flowers.
CC       {ECO:0000269|PubMed:12068116}.
CC   -!- MISCELLANEOUS: Gain-of-function mutant pck1-D (T-DNA tagging) shows
CC       highly epinastic leaves, reduced apical dominance and sterility.
CC   -!- SIMILARITY: Belongs to the LOB domain-containing protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB164306; BAD12425.1; -; mRNA.
DR   EMBL; AB473838; BAH10549.1; -; mRNA.
DR   EMBL; AC004165; AAC16959.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08349.1; -; Genomic_DNA.
DR   EMBL; AY086960; AAM64523.1; -; mRNA.
DR   PIR; T00585; T00585.
DR   RefSeq; NP_565695.1; NM_128568.2.
DR   AlphaFoldDB; Q8LBW3; -.
DR   SMR; Q8LBW3; -.
DR   BioGRID; 2914; 19.
DR   IntAct; Q8LBW3; 16.
DR   STRING; 3702.AT2G30130.1; -.
DR   PaxDb; Q8LBW3; -.
DR   PRIDE; Q8LBW3; -.
DR   ProteomicsDB; 250730; -.
DR   EnsemblPlants; AT2G30130.1; AT2G30130.1; AT2G30130.
DR   GeneID; 817565; -.
DR   Gramene; AT2G30130.1; AT2G30130.1; AT2G30130.
DR   KEGG; ath:AT2G30130; -.
DR   Araport; AT2G30130; -.
DR   TAIR; locus:2060842; AT2G30130.
DR   eggNOG; ENOG502RXPJ; Eukaryota.
DR   HOGENOM; CLU_058353_5_0_1; -.
DR   InParanoid; Q8LBW3; -.
DR   OMA; PEMENPD; -.
DR   OrthoDB; 1385805at2759; -.
DR   PhylomeDB; Q8LBW3; -.
DR   PRO; PR:Q8LBW3; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8LBW3; baseline and differential.
DR   Genevisible; Q8LBW3; AT.
DR   GO; GO:0003677; F:DNA binding; TAS:TAIR.
DR   GO; GO:0009965; P:leaf morphogenesis; IMP:TAIR.
DR   GO; GO:0010016; P:shoot system morphogenesis; IMP:TAIR.
DR   InterPro; IPR004883; LOB.
DR   Pfam; PF03195; LOB; 1.
DR   PROSITE; PS50891; LOB; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..193
FT                   /note="LOB domain-containing protein 12"
FT                   /id="PRO_0000132263"
FT   DOMAIN          7..108
FT                   /note="LOB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00291"
FT   CONFLICT        25
FT                   /note="F -> L (in Ref. 5; AAM64523)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   193 AA;  21529 MW;  2B59AEDF7E4D18E0 CRC64;
     MGGPGSSPCA SCKLLRRRCA KDCIFAPYFP PDDPHKFAIV HKVFGASNVS KMLQELPVHQ
     RADAVNSLVF EANARVRDPV YGCVGAISYL QNQVSQLQMQ LAVAQAEILC IQMQNEPTLQ
     SHHQVLELDQ DHKALLLNNN NINNCNTNNN NNNFGYAMSS GQFNSNFASP SSIMQMQMQM
     QMQDPLKQES LWT