LBD36_ARATH
ID LBD36_ARATH Reviewed; 313 AA.
AC Q9FKZ3; B5RID4; Q0WQZ4;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=LOB domain-containing protein 36;
DE AltName: Full=ASYMMETRIC LEAVES 2-like protein 1;
DE Short=AS2-like protein 1;
GN Name=LBD36; Synonyms=ASL1; OrderedLocusNames=At5g66870; ORFNames=MUD21.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=12040093; DOI=10.1093/pcp/pcf077;
RA Iwakawa H., Ueno Y., Semiarti E., Onouchi H., Kojima S., Tsukaya H.,
RA Hasebe M., Soma T., Ikezaki M., Machida C., Machida Y.;
RT "The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana, required for
RT formation of a symmetric flat leaf lamina, encodes a member of a novel
RT family of proteins characterized by cysteine repeats and a leucine
RT zipper.";
RL Plant Cell Physiol. 43:467-478(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19154202; DOI=10.1111/j.1365-313x.2009.03797.x;
RA Matsumura Y., Iwakawa H., Machida Y., Machida C.;
RT "Characterization of genes in the ASYMMETRIC LEAVES2/LATERAL ORGAN
RT BOUNDARIES (AS2/LOB) family in Arabidopsis thaliana, and functional and
RT molecular comparisons between AS2 and other family members.";
RL Plant J. 58:525-537(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J., Ecker J.R.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12068116; DOI=10.1104/pp.010926;
RA Shuai B., Reynaga-Pena C.G., Springer P.S.;
RT "The LATERAL ORGAN BOUNDARIES gene defines a novel, plant-specific gene
RT family.";
RL Plant Physiol. 129:747-761(2002).
RN [8]
RP FUNCTION.
RX PubMed=12787254; DOI=10.1046/j.1365-313x.2003.01758.x;
RA Nakazawa M., Ichikawa T., Ishikawa A., Kobayashi H., Tsuhara Y.,
RA Kawashima M., Suzuki K., Muto S., Matsui M.;
RT "Activation tagging, a novel tool to dissect the functions of a gene
RT family.";
RL Plant J. 34:741-750(2003).
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15821980; DOI=10.1007/s11103-005-0698-4;
RA Chalfun-Junior A., Franken J., Mes J.J., Marsch-Martinez N., Pereira A.,
RA Angenent G.C.;
RT "ASYMMETRIC LEAVES2-LIKE1 gene, a member of the AS2/LOB family, controls
RT proximal-distal patterning in Arabidopsis petals.";
RL Plant Mol. Biol. 57:559-575(2005).
CC -!- FUNCTION: Controls the proximal-distal patterning in petals and the
CC adaxial-abaxial determination of leaves. Involved in the repression of
CC the homeobox gene BP. {ECO:0000269|PubMed:12787254,
CC ECO:0000269|PubMed:15821980}.
CC -!- TISSUE SPECIFICITY: Expressed in trichomes, at the base of many lateral
CC organs, including branching points of the inflorescence and floral
CC organs and in the distal part of the pistil at stages when style and
CC stigma start to develop. Also detected in pedicels and at the base of
CC petals and sepals. {ECO:0000269|PubMed:15821980}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype; due to the partial
CC redundancy with AS2. Gain-of-function mutants iso-3D, iso-4D and dsl1-D
CC (T-DNA and transposon tagging) show flowers and siliques bended
CC downwards. {ECO:0000269|PubMed:12040093}.
CC -!- SIMILARITY: Belongs to the LOB domain-containing protein family.
CC {ECO:0000305}.
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DR EMBL; AB164303; BAD12422.1; -; mRNA.
DR EMBL; AB473834; BAH10545.1; -; mRNA.
DR EMBL; AB010700; BAB08629.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98273.1; -; Genomic_DNA.
DR EMBL; AK228533; BAF00455.1; -; mRNA.
DR EMBL; BT044058; ACH90465.1; -; mRNA.
DR RefSeq; NP_201488.1; NM_126086.7.
DR AlphaFoldDB; Q9FKZ3; -.
DR SMR; Q9FKZ3; -.
DR IntAct; Q9FKZ3; 1.
DR STRING; 3702.AT5G66870.1; -.
DR iPTMnet; Q9FKZ3; -.
DR PaxDb; Q9FKZ3; -.
DR PRIDE; Q9FKZ3; -.
DR ProteomicsDB; 238409; -.
DR EnsemblPlants; AT5G66870.1; AT5G66870.1; AT5G66870.
DR GeneID; 836821; -.
DR Gramene; AT5G66870.1; AT5G66870.1; AT5G66870.
DR KEGG; ath:AT5G66870; -.
DR Araport; AT5G66870; -.
DR TAIR; locus:2174989; AT5G66870.
DR eggNOG; ENOG502QSSJ; Eukaryota.
DR HOGENOM; CLU_058353_1_0_1; -.
DR InParanoid; Q9FKZ3; -.
DR OMA; PFNMNPM; -.
DR OrthoDB; 1388423at2759; -.
DR PhylomeDB; Q9FKZ3; -.
DR PRO; PR:Q9FKZ3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKZ3; baseline and differential.
DR GO; GO:0009965; P:leaf morphogenesis; IMP:TAIR.
DR GO; GO:0048441; P:petal development; IGI:TAIR.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR InterPro; IPR004883; LOB.
DR InterPro; IPR017414; LOBD.
DR Pfam; PF03195; LOB; 1.
DR PIRSF; PIRSF038155; Protein_ASYMMETRIC_LEAVES; 1.
DR PROSITE; PS50891; LOB; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..313
FT /note="LOB domain-containing protein 36"
FT /id="PRO_0000132251"
FT DOMAIN 6..107
FT /note="LOB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00291"
FT REGION 245..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 183
FT /note="N -> S (in Ref. 5; BAF00455)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 34523 MW; E8EB436AB6A94A97 CRC64;
MASSSSPCAA CKFLRRKCTQ ECVFAPYFPP DQPQKFAFVH KVFGASNVAK LLNELASNQR
EDAVNSLFYE AEARLRDPVY GCVGLISILQ HRLKQVNHDL ENAKKELATY VGPQAMLPIL
QPHFMSLPPQ PQRPSSSSAS VLTQHHHNLL PMMAIPTGQL YHQQQQQIFE AQQLAAVARE
QQNEMFRAYG GGGGSSSPHH QNQAQAEILR FNNGFDSVPA GSVTVTGFNQ LSSGGTAVTG
MSLGGNFVDS PSTNNNYHTD QQLHHHHQPQ QHHEAQLFIP SQSSQPLPLQ TQETQTQTQP
NSESEEGRRN VIG
