ID   LBD6_MAIZE              Reviewed;         260 AA.
AC   Q32SG3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=LOB domain-containing protein 6;
DE   AltName: Full=Protein ASYMMETRIC LEAVES 2;
DE   AltName: Full=Protein indeterminate gametophyte 1;
DE   AltName: Full=ZmIG1;
GN   Name=LBD6; Synonyms=AS2, IG1;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH RS2.
RC   TISSUE=Apices;
RX   PubMed=16243907; DOI=10.1105/tpc.105.035477;
RA   Phelps-Durr T.L., Thomas J., Vahab P., Timmermans M.C.P.;
RT   "Maize rough sheath2 and its Arabidopsis orthologue ASYMMETRIC LEAVES1
RT   interact with HIRA, a predicted histone chaperone, to maintain knox gene
RT   silencing and determinacy during organogenesis.";
RL   Plant Cell 17:2886-2898(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND FUNCTION.
RC   STRAIN=cv. B73;
RX   PubMed=17209126; DOI=10.1105/tpc.106.047506;
RA   Evans M.M.S.;
RT   "The indeterminate gametophyte1 gene of maize encodes a LOB domain protein
RT   required for embryo Sac and leaf development.";
RL   Plant Cell 19:46-62(2007).
CC   -!- FUNCTION: Promotes the switch from proliferation to differentiation in
CC       the embryo sac. Negative regulator of cell proliferation in the adaxial
CC       side of leaves. Regulates the formation of a symmetric lamina and the
CC       establishment of venation. Interacts directly with RS2 (rough sheath 2)
CC       to repress some knox homeobox genes. {ECO:0000269|PubMed:17209126}.
CC   -!- SUBUNIT: Interacts with RS2. {ECO:0000269|PubMed:16243907}.
CC   -!- INTERACTION:
CC       Q32SG3; Q9S7B2: RS2; NbExp=2; IntAct=EBI-761239, EBI-761350;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, leaf primordia, immature ears,
CC       immature tassels, whole ovules, silk and husk leaves. Found on the
CC       adaxial side of organs. {ECO:0000269|PubMed:17209126}.
CC   -!- DEVELOPMENTAL STAGE: In embryo sac, detected as early as the one-
CC       nucleus stage. In older embryo sacs, highest expression in antipodal
CC       cells. {ECO:0000269|PubMed:17209126}.
CC   -!- MISCELLANEOUS: Might be partially redundant with the IAL genes.
CC   -!- SIMILARITY: Belongs to the LOB domain-containing protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY940681; AAY24684.1; -; mRNA.
DR   EMBL; EF081454; ABM21683.1; -; Genomic_DNA.
DR   RefSeq; NP_001105838.1; NM_001112368.1.
DR   RefSeq; XP_008673456.1; XM_008675234.1.
DR   AlphaFoldDB; Q32SG3; -.
DR   SMR; Q32SG3; -.
DR   IntAct; Q32SG3; 1.
DR   STRING; 4577.GRMZM2G118250_P06; -.
DR   PaxDb; Q32SG3; -.
DR   PRIDE; Q32SG3; -.
DR   EnsemblPlants; Zm00001eb145150_T001; Zm00001eb145150_P001; Zm00001eb145150.
DR   EnsemblPlants; Zm00001eb145150_T003; Zm00001eb145150_P003; Zm00001eb145150.
DR   EnsemblPlants; Zm00001eb145150_T005; Zm00001eb145150_P005; Zm00001eb145150.
DR   GeneID; 732739; -.
DR   Gramene; Zm00001eb145150_T001; Zm00001eb145150_P001; Zm00001eb145150.
DR   Gramene; Zm00001eb145150_T003; Zm00001eb145150_P003; Zm00001eb145150.
DR   Gramene; Zm00001eb145150_T005; Zm00001eb145150_P005; Zm00001eb145150.
DR   KEGG; zma:732739; -.
DR   eggNOG; ENOG502QV43; Eukaryota.
DR   HOGENOM; CLU_058353_1_2_1; -.
DR   OMA; DEWAYVS; -.
DR   Proteomes; UP000007305; Chromosome 3.
DR   ExpressionAtlas; Q32SG3; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004883; LOB.
DR   Pfam; PF03195; LOB; 1.
DR   PROSITE; PS50891; LOB; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..260
FT                   /note="LOB domain-containing protein 6"
FT                   /id="PRO_0000299138"
FT   DOMAIN          32..133
FT                   /note="LOB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00291"
SQ   SEQUENCE   260 AA;  26721 MW;  1ADBFE1EE22D6DDF CRC64;
     MASSVPAPSG SVITVASSSS SAAAAAVCGT GSPCAACKFL RRKCQPDCVF APYFPPDNPQ
     KFVHVHRVFG ASNVTKLLNE LHPFQREDAV NSLAYEADMR LRDPVYGCVG VISILQHNLR
     QLQQDLARAK YELSKYQAAA AASASTAPTG PQAMAEFIGN AMPNGAHNFI NIGHSAALGS
     LGGSASVFGQ EQFGNAQMLS RSYDGGEPIA RLGINGGGYE FGYSTAMGGS GAVSGLGTLG
     ISPFLKSGTA GGDEKPNGGQ