LBH_HUMAN
ID LBH_HUMAN Reviewed; 105 AA.
AC Q53QV2; B2RBC2; Q9H0Q1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein LBH {ECO:0000305};
DE Short=hLBH {ECO:0000303|PubMed:17390236};
DE AltName: Full=Limb bud and heart development protein homolog {ECO:0000305};
GN Name=LBH {ECO:0000312|HGNC:HGNC:29532};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP SUBCELLULAR LOCATION, AND FUNCTION.
RC TISSUE=Embryonic heart;
RX PubMed=17390236; DOI=10.1007/s11033-007-9068-4;
RA Ai J., Wang Y., Tan K., Deng Y., Luo N., Yuan W., Wang Z., Li Y., Wang Y.,
RA Mo X., Zhu C., Yin Z., Liu M., Wu X.;
RT "A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates
RT SRE and AP-1 mediated MAPK signaling pathway.";
RL Mol. Biol. Rep. 35:179-187(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Transcriptional activator which may act in mitogen-activated
CC protein kinase signaling pathway. {ECO:0000269|PubMed:17390236}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17390236}. Cytoplasm
CC {ECO:0000269|PubMed:17390236}.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, and expressed at low
CC levels in placenta, lung, skeletal muscle, kidney and liver.
CC {ECO:0000269|PubMed:17390236}.
CC -!- DEVELOPMENTAL STAGE: Expressed in heart of 25 and 17 weeks embryos.
CC {ECO:0000269|PubMed:17390236}.
CC -!- SIMILARITY: Belongs to the LBH family. {ECO:0000305}.
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DR EMBL; EF025586; ABK30936.1; -; mRNA.
DR EMBL; AL136703; CAB66638.1; -; mRNA.
DR EMBL; AK314598; BAG37169.1; -; mRNA.
DR EMBL; AK223541; BAD97261.1; -; mRNA.
DR EMBL; AC104698; AAY24349.1; -; Genomic_DNA.
DR EMBL; BC109376; AAI09377.1; -; mRNA.
DR EMBL; BC126434; AAI26435.1; -; mRNA.
DR EMBL; BC130415; AAI30416.1; -; mRNA.
DR CCDS; CCDS33173.1; -.
DR RefSeq; NP_112177.2; NM_030915.3.
DR AlphaFoldDB; Q53QV2; -.
DR BioGRID; 123543; 22.
DR IntAct; Q53QV2; 4.
DR MINT; Q53QV2; -.
DR STRING; 9606.ENSP00000378733; -.
DR iPTMnet; Q53QV2; -.
DR PhosphoSitePlus; Q53QV2; -.
DR BioMuta; LBH; -.
DR EPD; Q53QV2; -.
DR jPOST; Q53QV2; -.
DR MassIVE; Q53QV2; -.
DR MaxQB; Q53QV2; -.
DR PaxDb; Q53QV2; -.
DR PeptideAtlas; Q53QV2; -.
DR PRIDE; Q53QV2; -.
DR ProteomicsDB; 62511; -.
DR Antibodypedia; 28981; 91 antibodies from 16 providers.
DR DNASU; 81606; -.
DR Ensembl; ENST00000395323.9; ENSP00000378733.3; ENSG00000213626.13.
DR GeneID; 81606; -.
DR KEGG; hsa:81606; -.
DR MANE-Select; ENST00000395323.9; ENSP00000378733.3; NM_030915.4; NP_112177.2.
DR UCSC; uc002rne.3; human.
DR CTD; 81606; -.
DR DisGeNET; 81606; -.
DR GeneCards; LBH; -.
DR HGNC; HGNC:29532; LBH.
DR HPA; ENSG00000213626; Low tissue specificity.
DR MIM; 611763; gene.
DR neXtProt; NX_Q53QV2; -.
DR OpenTargets; ENSG00000213626; -.
DR PharmGKB; PA162393798; -.
DR VEuPathDB; HostDB:ENSG00000213626; -.
DR eggNOG; ENOG502S1QG; Eukaryota.
DR GeneTree; ENSGT00390000009189; -.
DR InParanoid; Q53QV2; -.
DR OMA; CPLPCSD; -.
DR OrthoDB; 1541774at2759; -.
DR PhylomeDB; Q53QV2; -.
DR TreeFam; TF332770; -.
DR PathwayCommons; Q53QV2; -.
DR SignaLink; Q53QV2; -.
DR BioGRID-ORCS; 81606; 14 hits in 1082 CRISPR screens.
DR ChiTaRS; LBH; human.
DR GeneWiki; LBH; -.
DR GenomeRNAi; 81606; -.
DR Pharos; Q53QV2; Tbio.
DR PRO; PR:Q53QV2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q53QV2; protein.
DR Bgee; ENSG00000213626; Expressed in right lung and 187 other tissues.
DR ExpressionAtlas; Q53QV2; baseline and differential.
DR Genevisible; Q53QV2; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:2000103; P:positive regulation of mammary stem cell proliferation; IEA:Ensembl.
DR GO; GO:1904677; P:positive regulation of somatic stem cell division; IEA:Ensembl.
DR GO; GO:1904674; P:positive regulation of somatic stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0043408; P:regulation of MAPK cascade; IMP:UniProtKB.
DR InterPro; IPR013294; LBH.
DR InterPro; IPR038990; LBH_dom.
DR InterPro; IPR042945; LBH_dom_prot.
DR PANTHER; PTHR14987; PTHR14987; 1.
DR Pfam; PF15317; Lbh; 1.
DR PIRSF; PIRSF008130; LBH; 1.
DR PRINTS; PR01881; LBHPROTEIN.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Protein LBH"
FT /id="PRO_0000324802"
FT DOMAIN 18..104
FT /note="LBH"
FT /evidence="ECO:0000255"
FT REGION 86..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 63
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983,
FT ECO:0007744|PubMed:23186163"
FT CONFLICT 54
FT /note="C -> R (in Ref. 1; ABK30936 and 2; CAB66638)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 105 AA; 12217 MW; 384F05E5F3329CFF CRC64;
MSIYFPIHCP DYLRSAKMTE VMMNTQPMEE IGLSPRKDGL SYQIFPDPSD FDRCCKLKDR
LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETAK ENKEQ
