LBM_DROME
ID LBM_DROME Reviewed; 208 AA.
AC Q24188; Q9V4H0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein late bloomer;
GN Name=lbm; Synonyms=lbl; ORFNames=CG2374;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=8596956; DOI=10.1126/science.271.5257.1867;
RA Kopczynski C.C., Davis G.W., Goodman C.S.;
RT "A neural tetraspanin, encoded by late bloomer, that facilitates synapse
RT formation.";
RL Science 271:1867-1870(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Facilitates synapse formation. {ECO:0000269|PubMed:8596956}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Synapse.
CC -!- TISSUE SPECIFICITY: Transiently expressed on motor axons, growth cones
CC and terminal arbors. {ECO:0000269|PubMed:8596956}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; U49081; AAA98512.1; -; mRNA.
DR EMBL; AE013599; AAF59302.1; -; Genomic_DNA.
DR EMBL; AY071541; AAL49163.1; -; mRNA.
DR RefSeq; NP_001260757.1; NM_001273828.1.
DR RefSeq; NP_523639.1; NM_078915.3.
DR AlphaFoldDB; Q24188; -.
DR SMR; Q24188; -.
DR BioGRID; 61512; 1.
DR IntAct; Q24188; 1.
DR STRING; 7227.FBpp0088104; -.
DR TCDB; 8.A.40.1.4; the tetraspanin (tetraspanin) family.
DR PaxDb; Q24188; -.
DR PRIDE; Q24188; -.
DR DNASU; 35623; -.
DR EnsemblMetazoa; FBtr0089033; FBpp0088104; FBgn0016032.
DR EnsemblMetazoa; FBtr0336873; FBpp0307822; FBgn0016032.
DR GeneID; 35623; -.
DR KEGG; dme:Dmel_CG2374; -.
DR CTD; 35623; -.
DR FlyBase; FBgn0016032; lbm.
DR VEuPathDB; VectorBase:FBgn0016032; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000166294; -.
DR HOGENOM; CLU_055524_6_4_1; -.
DR InParanoid; Q24188; -.
DR OMA; SAQDYIH; -.
DR OrthoDB; 1275146at2759; -.
DR PhylomeDB; Q24188; -.
DR BioGRID-ORCS; 35623; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35623; -.
DR PRO; PR:Q24188; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0016032; Expressed in crop (Drosophila) and 35 other tissues.
DR ExpressionAtlas; Q24188; baseline and differential.
DR Genevisible; Q24188; DM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0007416; P:synapse assembly; IMP:FlyBase.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..208
FT /note="Protein late bloomer"
FT /id="PRO_0000219284"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 208 AA; 23005 MW; 5EC36525287B7AC9 CRC64;
MGCATTSVKI ASIVLNAVLG FLAAGAIGWI AYNADTETEE FVIAAYIACS LILVFALLGI
FAAIRESVVL TATSAVFLLI LAILQIVSTC LFLHEFDVKS GRDMVEVAWQ ANNMDSLQQK
HECCGQSSAQ DYIHLSLLIP PSCYADLQQT PDHLYLDGCI EKVQSFYESD KLRFIIVSWV
LVAFELICFA LAVFLAISFK NKQRRMEF
