ID   LBPA_NEIMA              Reviewed;         944 AA.
AC   Q9JTK4; A1ISV5;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Lactoferrin-binding protein A;
DE   Flags: Precursor;
GN   Name=lbpA; OrderedLocusNames=NMA1739;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Unknown. May be an iron-siderophore receptor.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AL157959; CAM08867.1; -; Genomic_DNA.
DR   PIR; C81798; C81798.
DR   RefSeq; WP_002247017.1; NC_003116.1.
DR   AlphaFoldDB; Q9JTK4; -.
DR   SMR; Q9JTK4; -.
DR   PRIDE; Q9JTK4; -.
DR   EnsemblBacteria; CAM08867; CAM08867; NMA1739.
DR   KEGG; nma:NMA1739; -.
DR   HOGENOM; CLU_008287_19_0_4; -.
DR   OMA; QLNRWVE; -.
DR   BioCyc; NMEN122587:NMA_RS08795-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015091; F:ferric iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR010948; TonB_lacto/transferrin_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   TIGRFAMs; TIGR01776; TonB-tbp-lbp; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Signal; TonB box; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..944
FT                   /note="Lactoferrin-binding protein A"
FT                   /id="PRO_0000034765"
FT   MOTIF           927..944
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   944 AA;  105733 MW;  CE06B6192E74AE3E CRC64;
     MNKKHGFSLT LTALAIAAAF PSYAANPETA ASDAAQSQSL KEITVRAAKV GRRSKEATGL
     GKIVKTSETL NKEQVLGIRD LTRYDPGVAV VEQGNGASGG YSIRGVDKNR VAVSVDGVAQ
     IQAFTVQGSL SGYGGRGGSG AINEIEYENI STVEIDKGAG SSDHGSGALG GAVAFRTKEA
     ADLISDGKSW GIQAKTAYGS KNRQFMKSLG AGFSKDGWEG LLIRTERQGR ETRPHGDIAD
     GVEYGIDRLD AFRQTYDIQK QNKKAEYFLA EGEREPKPVA KLAGNGNYLK NQLNRWVEER
     KKNNQPLNAE EEAMVREAQA RHENLSAQSY TGGGRILPDP MDYRSGSWLA KLGYRFGGRH
     YVGGVFEDTK QRYDIRDMTE KQYYGTDEAK KFSNKSGVYD GNDFRDGLYF VPNIEEWKGD
     TNLVKGIGLK YSRTKFIDEH HRRRRMGLLY RYENEAYSDN WADKAVLSFD KQGVATDNNT
     LKLNCAVYPA VDKSCRASAD KPYSYDSSDR FHYREQHNVL NASFEKSLKN KWTKHHLTLG
     FGYDASKAIS RPEQLSHNAA RISESTGFDD NNQDKYLLGK PEVVEGSVCG YIETLRSRKC
     VPRKINGSNI HISLNDRFSI GKYFDFSLGG RYDRQNFTTS EELVRSGRYV DRSWNSGIVF
     KPNRHFSVSY RASSGFRTPS FQELFGIDIY HDYPKGWQRP ALKSEKAANR EIGLQWKGDF
     GFLEISSFRN RYTDMIAVAD HKTQLPDSTG RLTEIDIRDY YNAQNMSLQG VNILGKIDWN
     GVYGKLPEGL YTTLAYNRIK PKSVSNRPDL SLRSYALDAV QPSRYVLGFG YDQPEGKWGA
     NIMLTYSKGK NPDELAYLAG DQKRYSTKRA SSSWSTADVS AYLNLKKRLT LRAAIYNIGN
     YRYVTWESLR QTAESTANRH GGDSNYGRYA APGRNFSLAL EMKF