LBPA_NEIMB
ID LBPA_NEIMB Reviewed; 943 AA.
AC Q06379; Q9JYK5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Lactoferrin-binding protein A;
DE AltName: Full=Iron-regulated outer membrane protein A;
DE Flags: Precursor;
GN Name=lbpA; Synonyms=iroA; OrderedLocusNames=NMB1540;
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BNCV / Serogroup B;
RX PubMed=8406871; DOI=10.1128/iai.61.11.4724-4733.1993;
RA Pettersson A., van der Ley P., Poolman J.T., Tommassen J.;
RT "Molecular characterization of the 98-kilodalton iron-regulated outer
RT membrane protein of Neisseria meningitidis.";
RL Infect. Immun. 61:4724-4733(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58;
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
CC -!- FUNCTION: Unknown. May be an iron-siderophore receptor.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- INDUCTION: By iron starvation.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X69214; CAA49148.1; -; Genomic_DNA.
DR EMBL; AE002098; AAF41895.1; -; Genomic_DNA.
DR PIR; G81070; G81070.
DR RefSeq; NP_274547.1; NC_003112.2.
DR RefSeq; WP_002247545.1; NC_003112.2.
DR AlphaFoldDB; Q06379; -.
DR SMR; Q06379; -.
DR STRING; 122586.NMB1540; -.
DR PaxDb; Q06379; -.
DR EnsemblBacteria; AAF41895; AAF41895; NMB1540.
DR KEGG; nme:NMB1540; -.
DR PATRIC; fig|122586.8.peg.1967; -.
DR HOGENOM; CLU_008287_19_0_4; -.
DR OMA; QLNRWVE; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0015091; F:ferric iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR InterPro; IPR010948; TonB_lacto/transferrin_rcpt.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR TIGRFAMs; TIGR01776; TonB-tbp-lbp; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 2: Evidence at transcript level;
KW Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..943
FT /note="Lactoferrin-binding protein A"
FT /id="PRO_0000034766"
FT MOTIF 926..943
FT /note="TonB C-terminal box"
FT CONFLICT 8
FT /note="P -> Q (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 16..18
FT /note="IAT -> VAA (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="A -> S (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 26..31
FT /note="QAGGAT -> NPETAA (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="I -> V (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="V -> A (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="R -> H (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="E -> A (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="D -> N (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 257..269
FT /note="DIKRKTREPFFSV -> GIKKPSEGGEYFLA (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 273..275
FT /note="RES -> SEL (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="L -> V (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 284..286
FT /note="YGK -> NGN (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 313
FT /note="Q -> M (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 389
FT /note="E -> K (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 420..423
FT /note="KNLV -> QKLI (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 455
FT /note="A -> K (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 546
FT /note="K -> N (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 564..572
FT /note="STGFDENNQ -> YSDYTDKG (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 658
FT /note="L -> V (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
FT CONFLICT 667
FT /note="V -> L (in Ref. 1; CAA49148)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 943 AA; 105681 MW; BD569ECACFC01A84 CRC64;
MNKKHGFPLT LTALAIATAF PAYAAQAGGA TPDAAQTQSL KEITVRAAKV GRRSKEATGL
GKIVKTSETL NKEQVLGIRD LTRYDPGVAV VEQGNGASGG YSIRGVDKNR VAVSVDGVAQ
IQAFTVQGSL SGYGGRGGSG AINEIEYENI STVEIDKGAG SSDHGSGALG GAVAFRTKEA
ADLISDGKSW GIQAKTAYGS KNRQFMKSLG AGFSKDGWEG LLIRTERQGR ETRPHGDIAD
GVEYGIDRLD AFRQTYDIKR KTREPFFSVE GERESKPVAK LAGYGKYLNN QLNRWVKERI
EQNQPLSAEE EAQVREAQAR HENLSAQAYT GGGRILPDPM DYRSGSWLAK LGYRFGGRHY
VGGVFEDTKQ RYDIRDMTEK QYYGTDEAEK FRDKSGVYDG DDFRDGLYFV PNIEEWKGDK
NLVRGIGLKY SRTKFIDEHH RRRRMGLLYR YENEAYSDNW ADKAVLSFDK QGVATDNNTL
KLNCAVYPAV DKSCRASADK PYSYDSSDRF HYREQHNVLN ASFEKSLKNK WTKHHLTLGF
GYDASKAISR PEQLSHNAAR ISESTGFDEN NQDKYLLGKP EVVEGSVCGY IETLRSRKCV
PRKINGSNIH ISLNDRFSIG KYFDFSLGGR YDRKNFTTSE ELVRSGRYVD RSWNSGILFK
PNRHFSVSYR ASSGFRTPSF QELFGIDIYH DYPKGWQRPA LKSEKAANRE IGLQWKGDFG
FLEISSFRNR YTDMIAVADH KTKLPNQAGQ LTEIDIRDYY NAQNMSLQGV NILGKIDWNG
VYGKLPEGLY TTLAYNRIKP KSVSNRPGLS LRSYALDAVQ PSRYVLGFGY DQPEGKWGAN
IMLTYSKGKN PDELAYLAGD QKRYSTKRAS SSWSTADVSA YLNLKKRLTL RAAIYNIGNY
RYVTWESLRQ TAESTANRHG GDSNYGRYAA PGRNFSLALE MKF
