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LBP_RENRE
ID   LBP_RENRE               Reviewed;         184 AA.
AC   P05938;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Luciferin-binding protein;
DE            Short=LBP;
OS   Renilla reniformis (Sea pansy).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Octocorallia; Pennatulacea;
OC   Sessiliflorae; Renillidae; Renilla.
OX   NCBI_TaxID=6136;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=1974522; DOI=10.1016/0014-5793(90)81029-n;
RA   Kumar S., Harrylock M., Walsh K.A., Cormier M.J., Charbonneau H.;
RT   "Amino acid sequence of the Ca2(+)-triggered luciferin binding protein of
RT   Renilla reniformis.";
RL   FEBS Lett. 268:287-290(1990).
CC   -!- FUNCTION: This Ca(2+)-dependent protein binds to luciferin. The
CC       luciferin of LBP is capable of reacting with luciferase and O(2) only
CC       when calcium is bound.
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DR   PIR; S11057; S11057.
DR   AlphaFoldDB; P05938; -.
DR   SMR; P05938; -.
DR   PRIDE; P05938; -.
DR   EvolutionaryTrace; P05938; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13202; EF-hand_5; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Luminescence; Metal-binding;
KW   Photoprotein; Repeat.
FT   CHAIN           1..184
FT                   /note="Luciferin-binding protein"
FT                   /id="PRO_0000073469"
FT   DOMAIN          10..45
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          46..81
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          98..133
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          134..169
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         111
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         113
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         115
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         117
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         122
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         147
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         149
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         151
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         153
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         158
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   184 AA;  20539 MW;  D727FCFA7579E7CE CRC64;
     PEVTASERAY HLRKMKTRMK RVDVTGDGFI SREDYELIAV RIAKIAKLSA EKAEETRQEF
     LRVADQLGLA PGVRISVEEA AVNATDSLLK MKAEEKAMAV IQSLIMYDCI DTDKDGYVSL
     PEFKAFLQAV GPDITDDKAI TCFNTLDFNK NGQISRDEFL VTVNDFLFGL EETALANAFY
     GDLL
 
 
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