LBP_RENRE
ID LBP_RENRE Reviewed; 184 AA.
AC P05938;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Luciferin-binding protein;
DE Short=LBP;
OS Renilla reniformis (Sea pansy).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Octocorallia; Pennatulacea;
OC Sessiliflorae; Renillidae; Renilla.
OX NCBI_TaxID=6136;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=1974522; DOI=10.1016/0014-5793(90)81029-n;
RA Kumar S., Harrylock M., Walsh K.A., Cormier M.J., Charbonneau H.;
RT "Amino acid sequence of the Ca2(+)-triggered luciferin binding protein of
RT Renilla reniformis.";
RL FEBS Lett. 268:287-290(1990).
CC -!- FUNCTION: This Ca(2+)-dependent protein binds to luciferin. The
CC luciferin of LBP is capable of reacting with luciferase and O(2) only
CC when calcium is bound.
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DR PIR; S11057; S11057.
DR AlphaFoldDB; P05938; -.
DR SMR; P05938; -.
DR PRIDE; P05938; -.
DR EvolutionaryTrace; P05938; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW Calcium; Direct protein sequencing; Luminescence; Metal-binding;
KW Photoprotein; Repeat.
FT CHAIN 1..184
FT /note="Luciferin-binding protein"
FT /id="PRO_0000073469"
FT DOMAIN 10..45
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 46..81
FT /note="EF-hand 2"
FT /evidence="ECO:0000305"
FT DOMAIN 98..133
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 134..169
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 111
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 113
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 115
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 117
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 122
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 147
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 149
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 151
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 153
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 158
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 184 AA; 20539 MW; D727FCFA7579E7CE CRC64;
PEVTASERAY HLRKMKTRMK RVDVTGDGFI SREDYELIAV RIAKIAKLSA EKAEETRQEF
LRVADQLGLA PGVRISVEEA AVNATDSLLK MKAEEKAMAV IQSLIMYDCI DTDKDGYVSL
PEFKAFLQAV GPDITDDKAI TCFNTLDFNK NGQISRDEFL VTVNDFLFGL EETALANAFY
GDLL
