ID   LBX1B_DANRE             Reviewed;         265 AA.
AC   E7FDX5; F1QS21;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 3.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transcription factor LBX1b {ECO:0000303|PubMed:19216761};
DE   AltName: Full=Ladybird homeobox 1b {ECO:0000312|ZFIN:ZDB-GENE-050309-27};
GN   Name=lbx1b {ECO:0000312|ZFIN:ZDB-GENE-050309-27};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN   [1] {ECO:0000312|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=19216761; DOI=10.1186/1471-213x-9-13;
RA   Ochi H., Westerfield M.;
RT   "Lbx2 regulates formation of myofibrils.";
RL   BMC Dev. Biol. 9:13-13(2009).
CC   -!- FUNCTION: Transcription factor required for the development of hypaxial
CC       muscles. {ECO:0000269|PubMed:19216761}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|RuleBase:RU000682}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at the dorsal intermediate region
CC       of the neural tube at the 5-somite stage, expression is extended along
CC       the rostral caudal axis by the late stages of segmentation
CC       (PubMed:19216761). Expressed at the presumptive fin bud at 24 hours
CC       post-fertilization (hpf) and then at the fin bud at 48 hpf
CC       (PubMed:19216761). {ECO:0000269|PubMed:19216761}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown results in decreased myod1
CC       expression in the fin bud of embryos. {ECO:0000269|PubMed:19216761}.
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DR   EMBL; CR855357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT573247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001156784.1; NM_001163312.1.
DR   AlphaFoldDB; E7FDX5; -.
DR   SMR; E7FDX5; -.
DR   STRING; 7955.ENSDARP00000014246; -.
DR   PaxDb; E7FDX5; -.
DR   Ensembl; ENSDART00000007770; ENSDARP00000014246; ENSDARG00000018611.
DR   GeneID; 793810; -.
DR   KEGG; dre:793810; -.
DR   CTD; 793810; -.
DR   ZFIN; ZDB-GENE-050309-27; lbx1b.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000164611; -.
DR   HOGENOM; CLU_086390_0_0_1; -.
DR   InParanoid; E7FDX5; -.
DR   OMA; HEREITH; -.
DR   OrthoDB; 1472248at2759; -.
DR   PhylomeDB; E7FDX5; -.
DR   TreeFam; TF325047; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000018611; Expressed in hindbrain and 18 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0060026; P:convergent extension; IMP:ZFIN.
DR   GO; GO:0042692; P:muscle cell differentiation; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..265
FT                   /note="Transcription factor LBX1b"
FT                   /id="PRO_0000451739"
FT   DNA_BIND        121..180
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   265 AA;  29510 MW;  B721CDE0F732AD1A CRC64;
     MTTIKVVKIC GAMESRGLNP LDHLPPPASS NKPLTPFSIT DILSKPTVKR FHRIHRLPAS
     DRVRQSITVS RQTLITQASP LCALQELASK TFKGLELGVL QAAEGKDGLK LFGQRDSPKK
     RRKSRTAFTN HQLYELEKRF LHQKYLSPAD RDQIAHQLGL TNAQVITWFQ NRRAKLKRDL
     EEMKADVESV RSTGLVPLDK LAKLADLERC AAAGATGNPG PQCSPRLGHE YKTVHKLCLS
     PMSSLSDHTS QDCSEDEEVE IDVDV