ID   LBX1_RAT                Reviewed;         285 AA.
AC   Q1XID0;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transcription factor LBX1;
DE   AltName: Full=Ladybird homeobox protein homolog 1;
GN   Name=Lbx1 {ECO:0000312|EMBL:BAE92722.1};
GN   Synonyms=Lbx1h {ECO:0000250|UniProtKB:P52955};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:BAE92722.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:BAE92722.1};
RC   TISSUE=Embryo {ECO:0000312|EMBL:BAE92722.1};
RA   Takahashi M., Osumi N.;
RT   "Expressions of homeobox and bHLH transcription factors in the developing
RT   hindbrain.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor required for the development of
CC       GABAergic interneurons in the dorsal horn of the spinal cord and
CC       migration and further development of hypaxial muscle precursor cells
CC       for limb muscles, diaphragm and hypoglossal cord.
CC       {ECO:0000250|UniProtKB:P52955}.
CC   -!- SUBUNIT: Interacts with SKOR1 which acts as a transcriptional
CC       corepressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AB197923; BAE92722.1; -; mRNA.
DR   RefSeq; NP_001040573.1; NM_001047108.1.
DR   AlphaFoldDB; Q1XID0; -.
DR   SMR; Q1XID0; -.
DR   STRING; 10116.ENSRNOP00000021747; -.
DR   PaxDb; Q1XID0; -.
DR   PRIDE; Q1XID0; -.
DR   Ensembl; ENSRNOT00000021748; ENSRNOP00000021747; ENSRNOG00000025520.
DR   GeneID; 499362; -.
DR   KEGG; rno:499362; -.
DR   CTD; 10660; -.
DR   RGD; 1564197; Lbx1.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000161756; -.
DR   HOGENOM; CLU_086390_0_0_1; -.
DR   InParanoid; Q1XID0; -.
DR   OMA; ADKHSPG; -.
DR   OrthoDB; 1472248at2759; -.
DR   PhylomeDB; Q1XID0; -.
DR   TreeFam; TF325047; -.
DR   PRO; PR:Q1XID0; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000025520; Expressed in quadriceps femoris and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:1905962; P:glutamatergic neuron differentiation; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; ISO:RGD.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0120007; P:negative regulation of glutamatergic neuron differentiation; IEA:Ensembl.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; ISO:RGD.
DR   GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
DR   GO; GO:0048664; P:neuron fate determination; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Myogenesis;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..285
FT                   /note="Transcription factor LBX1"
FT                   /id="PRO_0000260041"
FT   DNA_BIND        125..184
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..285
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  30433 MW;  3F38D2211EE29C49 CRC64;
     MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL
     AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ
     TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL
     KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEASGG GGGGGGGGCG RAKSRPGSPA
     LPPGAPQAPG GGPLQLSPAS PLTDQRASSQ DCSEDEEDEE IDVDD