ID   LBX1_XENLA              Reviewed;         267 AA.
AC   Q2PYN8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Transcription factor LBX1;
DE   AltName: Full=Ladybird homeobox protein homolog 1;
GN   Name=lbx1 {ECO:0000312|EMBL:ABC49635.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABC49635.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16339190; DOI=10.1242/dev.02183;
RA   Martin B.L., Harland R.M.;
RT   "A novel role for lbx1 in Xenopus hypaxial myogenesis.";
RL   Development 133:195-208(2006).
CC   -!- FUNCTION: Transcription factor that controls hypaxial muscle
CC       development by down-regulating myod1 and cdkn1b/p27, thereby allowing
CC       myoblasts to proliferate before the onset of terminal differentiation.
CC       {ECO:0000269|PubMed:16339190}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in all myoblasts that will populate body
CC       wall muscles as well as in a group of cells the migrate into the head.
CC       {ECO:0000269|PubMed:16339190}.
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DR   EMBL; DQ294722; ABC49635.1; -; mRNA.
DR   RefSeq; NP_001089192.1; NM_001095723.1.
DR   GeneID; 734237; -.
DR   KEGG; xla:734237; -.
DR   CTD; 734237; -.
DR   Xenbase; XB-GENE-6251676; lbx1.L.
DR   OrthoDB; 1472248at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 734237; Expressed in muscle tissue and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IMP:UniProtKB.
DR   GO; GO:0051450; P:myoblast proliferation; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Myogenesis;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..267
FT                   /note="Transcription factor LBX1"
FT                   /id="PRO_0000271250"
FT   DNA_BIND        127..186
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..249
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  29596 MW;  C8D9927F4F6FAAA3 CRC64;
     MTSKDEAKSS ASSVEERRRN ALDLLPPPAN SNKPLTPFSI EDILNKPSVR RSYTICGTAH
     LLSSADKPPA AGLPLSSRAL LSQTSPLCAL EELASKTFKG LEVSVLQAAE GRDGMTIFGQ
     RQTPKKRRKS RTAFTNHQIY ELEKRFLYQK YLSPADRDQI AQQLGLTNAQ VITWFQNRRA
     KLKRDLEEMK ADVESTKKMS PSAVEAVLTI SELEESGSER GNSRSRSPQL GLTSNHMPLS
     PSXPLTDQHA SKECSEDEED VEIDVDD