ID   LBX1_XENTR              Reviewed;         265 AA.
AC   Q0P4H6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transcription factor LBX1;
DE   AltName: Full=Ladybird homeobox protein homolog 1;
GN   Name=lbx1 {ECO:0000250|UniProtKB:Q2PYN8};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI22078.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000312|EMBL:AAI22078.1};
RC   TISSUE=Skeletal muscle {ECO:0000312|EMBL:AAI22078.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that controls hypaxial muscle
CC       development by down-regulating myod1 and cdkn1b/p27, thereby allowing
CC       myoblasts to proliferate before the onset of terminal differentiation.
CC       {ECO:0000250|UniProtKB:Q2PYN8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC122077; AAI22078.1; -; mRNA.
DR   RefSeq; NP_001072559.1; NM_001079091.1.
DR   AlphaFoldDB; Q0P4H6; -.
DR   SMR; Q0P4H6; -.
DR   DNASU; 780014; -.
DR   GeneID; 780014; -.
DR   KEGG; xtr:780014; -.
DR   CTD; 10660; -.
DR   Xenbase; XB-GENE-6455157; lbx1.
DR   InParanoid; Q0P4H6; -.
DR   OrthoDB; 1472248at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000040868; Expressed in skeletal muscle tissue and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; ISS:UniProtKB.
DR   GO; GO:0051450; P:myoblast proliferation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Myogenesis;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..265
FT                   /note="Transcription factor LBX1"
FT                   /id="PRO_0000271251"
FT   DNA_BIND        125..184
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29608 MW;  CC3449BB6687D478 CRC64;
     MTSKDEAKSS SVEERRRHAL DLLPPPANSN KPLTPFSIED ILNKPSVRRS YTICGTAHLL
     STAEKPPAAG LPLSSRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ
     TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL
     KRDLEEMKAD VESVKKMSPS TVEAVLTISE LEEETNSVRD DSRSRSPQLG LSGHMPLSPS
     SPLTEQHTSK ECSEDEEDVE IDVDD