LBX2_MOUSE
ID LBX2_MOUSE Reviewed; 195 AA.
AC Q9WUN8; Q32M12;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Transcription factor LBX2;
DE AltName: Full=Ladybird homeobox 2 {ECO:0000250|UniProtKB:Q6XYB7};
DE AltName: Full=Ladybird homeobox protein homolog 2;
GN Name=Lbx2; Synonyms=Lbx2h {ECO:0000312|MGI:MGI:1342288};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=10473138; DOI=10.1016/s0925-4773(99)00073-8;
RA Chen F., Liu K.C., Epstein J.A.;
RT "Lbx2, a novel murine homeobox gene related to the Drosophila ladybird
RT genes is expressed in the developing urogenital system, eye and brain.";
RL Mech. Dev. 84:181-184(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=11386758; DOI=10.1006/geno.2001.6539;
RA Chen F., Collin G.B., Liu K.C., Beier D.R., Eccles M., Nishina P.M.,
RA Moshang T., Epstein J.A.;
RT "Characterization of the murine Lbx2 promoter, identification of the human
RT homologue, and evaluation as a candidate for Alstrom syndrome.";
RL Genomics 74:219-227(2001).
RN [5]
RP DISRUPTION PHENOTYPE, AND INDUCTION.
RX PubMed=17492753; DOI=10.1002/dvg.20302;
RA Wei K., Chen J., Akrami K., Sekhon R., Chen F.;
RT "Generation of mice deficient for Lbx2, a gene expressed in the urogenital
RT system, nervous system, and Pax3 dependent tissues.";
RL Genesis 45:361-368(2007).
CC -!- FUNCTION: Transcription factor. {ECO:0000250|UniProtKB:Q804R0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the developing urogenital system, eye
CC and brain. {ECO:0000269|PubMed:10473138}.
CC -!- DEVELOPMENTAL STAGE: First detected at 10.5 dpc in the gonadal
CC component of the urogenital ridge. Expression dramatically increases by
CC 11.5 dpc in the urogenital ridges and in the cranial surface ectoderm.
CC At this time, it is also expressed in the trigeminal ganglion and
CC nodose ganglion. At later stages, it is expressed in the brain and
CC organs derived from the urogenital ridge, including the gonadal
CC tubercle, kidneys, and adrenal glands. From 14.5 dpc to birth,
CC expression is evident in the developing retinal neuroepithelium and the
CC vibrissa. {ECO:0000269|PubMed:10473138, ECO:0000269|PubMed:11386758}.
CC -!- INDUCTION: By PAX3 which regulates its expression.
CC {ECO:0000269|PubMed:17492753}.
CC -!- DISRUPTION PHENOTYPE: Mice are healthy and fertile and do not display
CC any abnormal phenotype. {ECO:0000269|PubMed:17492753}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF146150; AAD31905.1; -; mRNA.
DR EMBL; AK002897; BAB22441.1; -; mRNA.
DR EMBL; BC109347; AAI09348.1; -; mRNA.
DR CCDS; CCDS20271.1; -.
DR RefSeq; NP_034822.1; NM_010692.3.
DR AlphaFoldDB; Q9WUN8; -.
DR SMR; Q9WUN8; -.
DR STRING; 10090.ENSMUSP00000047134; -.
DR PaxDb; Q9WUN8; -.
DR PRIDE; Q9WUN8; -.
DR Antibodypedia; 31549; 120 antibodies from 16 providers.
DR DNASU; 16815; -.
DR Ensembl; ENSMUST00000041265; ENSMUSP00000047134; ENSMUSG00000034968.
DR GeneID; 16815; -.
DR KEGG; mmu:16815; -.
DR UCSC; uc009cmi.1; mouse.
DR CTD; 85474; -.
DR MGI; MGI:1342288; Lbx2.
DR VEuPathDB; HostDB:ENSMUSG00000034968; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000162295; -.
DR HOGENOM; CLU_086390_0_0_1; -.
DR InParanoid; Q9WUN8; -.
DR OMA; MNSGRQP; -.
DR OrthoDB; 1472248at2759; -.
DR PhylomeDB; Q9WUN8; -.
DR TreeFam; TF325047; -.
DR BioGRID-ORCS; 16815; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9WUN8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9WUN8; protein.
DR Bgee; ENSMUSG00000034968; Expressed in female urethra and 48 other tissues.
DR Genevisible; Q9WUN8; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0042692; P:muscle cell differentiation; ISS:UniProtKB.
DR GO; GO:1904105; P:positive regulation of convergent extension involved in gastrulation; ISS:UniProtKB.
DR GO; GO:2000052; P:positive regulation of non-canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..195
FT /note="Transcription factor LBX2"
FT /id="PRO_0000311329"
FT DNA_BIND 84..143
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 173
FT /note="P -> S (in Ref. 3; AAI09348)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 20917 MW; E106CE108933DE45 CRC64;
MNSVHQRRTP FSIADILGPS MVPEAPSAPQ LPEAGPDPAS PLCALEELAS KTFLGHSPRA
TPQPSEGRAA PEAPPGPGAG VRRRRKSRTA FTAQQVLELE RRFVFQKYLA PSERDGLAAR
LGLANAQVVT WFQNRRAKLK RDVEEMRADV ASLCGLSPGV LCYPALPDST SSPDPGPSGP
DSEPNLSDEE IQVDD
