ID   LCA5L_MACFA             Reviewed;         668 AA.
AC   Q4R3Q7; Q4R634;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Lebercilin-like protein;
DE   AltName: Full=Leber congenital amaurosis 5-like protein;
GN   Name=LCA5L {ECO:0000250|UniProtKB:O95447}; ORFNames=QtsA-14985, QtsA-19247;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000312|EMBL:BAE02259.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:BAE02259.1};
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LCA5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE01441.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAE01441.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=BAE02259.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB169356; BAE01441.1; ALT_SEQ; mRNA.
DR   EMBL; AB179208; BAE02259.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q4R3Q7; -.
DR   SMR; Q4R3Q7; -.
DR   STRING; 9541.XP_005548725.1; -.
DR   PRIDE; Q4R3Q7; -.
DR   eggNOG; ENOG502QQSE; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   InterPro; IPR026188; Lebercilin-like.
DR   InterPro; IPR028933; Lebercilin_dom.
DR   PANTHER; PTHR16650; PTHR16650; 1.
DR   Pfam; PF15619; Lebercilin; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..668
FT                   /note="Lebercilin-like protein"
FT                   /id="PRO_0000331228"
FT   REGION          17..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..581
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          148..259
FT                   /evidence="ECO:0000255"
FT   COILED          305..336
FT                   /evidence="ECO:0000255"
FT   COILED          420..440
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        354..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..573
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        291
FT                   /note="V -> A (in Ref. 1; BAE01441)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        398
FT                   /note="H -> R (in Ref. 1; BAE01441)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        458
FT                   /note="K -> R (in Ref. 1; BAE01441)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        565
FT                   /note="M -> I (in Ref. 1; BAE01441)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        633
FT                   /note="P -> PLP (in Ref. 1; BAE01441)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   668 AA;  76282 MW;  0E78D02037CD78E1 CRC64;
     MSLADLTKTN VDEQFSSVAL ENNRRSAECK RSPGTGDFSR NSSASAKSVD YSRSQCSCGS
     LSSQYDYSED FLCDCSEKAI NRNYLKQPVV KEKEKKKYNV SKISQSKGQK EISVEKKHTW
     NASLFNSQIH MIAQRRDAMA HRILSARLHK IKGLKNELAD MHHKLEAILT ENQFLKQLQL
     RHLKAIGKYE NSQNNLPQIM AKHQNEVKNL RQLLRKSQEK ERTVSRKLRE TDSQLLKTKD
     TLQALQKLSE DKNLAEREEL THKLSIITTK MEANDKKIQS LEKQLRLNSR VFSRQLAIET
     RKTLAAQTAT KTLQVEVKHL QQKLKEKDRE LEIKNIYSHR ILKNLHDTED YPKVSSTKSV
     QADRKSLPFT SMRHQGTQKS DVPPLTTKGK KATGNMNHKE KSTEINREIP HCVNKLPKQE
     DSKTKYEDLS REEKHLEVQV LLENTGRQKD KKEDQEKKTI FVKEEQELPP KIIEVIHPER
     ESTQEDVLVR EKFKRSMQRN GMDDTPDKCT APYTKGPLRQ RRHYSFTEAT ENLHHGLPAS
     GGPANAGNTK YSHSTSKHLS NREEMELEHS DSGYEPSFGK SSRIKVKDTT FRDKKSSLME
     ELFGSGYVLK TDQSSPGVAK GSEEPLQSKE SHPPSQASAS NAFGDSKVTV VNSIKPSSPT
     EGKRKIII