ID   LCAT1_ORYSJ             Reviewed;         434 AA.
AC   Q10PI6; A0A0P0VVA7; B7E586; Q0DTQ4; Q10PI7; Q8S5X5;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Lecithin-cholesterol acyltransferase-like 1;
DE            EC=2.3.1.-;
GN   OrderedLocusNames=Os03g0232800, LOC_Os03g13030; ORFNames=OJ1175C11.13;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q10PI6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q10PI6-2; Sequence=VSP_055462;
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM19133.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: Os03g0232800 and Os03g0232900.; Evidence={ECO:0000305};
CC       Sequence=BAF11384.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAG87533.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=BAH00268.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR   EMBL; AC103891; AAM19133.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000009; ABF94809.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF94810.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF11384.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP014959; BAS83121.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS83122.1; -; Genomic_DNA.
DR   EMBL; AK060669; BAG87533.1; ALT_SEQ; mRNA.
DR   EMBL; AK072207; BAG92871.1; -; mRNA.
DR   EMBL; AK121004; BAH00268.1; ALT_SEQ; mRNA.
DR   RefSeq; XP_015628714.1; XM_015773228.1. [Q10PI6-1]
DR   RefSeq; XP_015628715.1; XM_015773229.1. [Q10PI6-2]
DR   AlphaFoldDB; Q10PI6; -.
DR   SMR; Q10PI6; -.
DR   STRING; 4530.OS03T0232800-02; -.
DR   ESTHER; orysa-Q8S5X5; PC-sterol_acyltransferase.
DR   PaxDb; Q10PI6; -.
DR   PRIDE; Q10PI6; -.
DR   EnsemblPlants; Os03t0232800-01; Os03t0232800-01; Os03g0232800. [Q10PI6-2]
DR   EnsemblPlants; Os03t0232800-02; Os03t0232800-02; Os03g0232800. [Q10PI6-1]
DR   GeneID; 4332160; -.
DR   Gramene; Os03t0232800-01; Os03t0232800-01; Os03g0232800. [Q10PI6-2]
DR   Gramene; Os03t0232800-02; Os03t0232800-02; Os03g0232800. [Q10PI6-1]
DR   KEGG; osa:4332160; -.
DR   eggNOG; KOG2369; Eukaryota.
DR   OMA; HIKSNIP; -.
DR   OrthoDB; 828056at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   Genevisible; Q10PI6; OS.
DR   GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR   Pfam; PF02450; LCAT; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Alternative splicing; Reference proteome; Transferase.
FT   CHAIN           1..434
FT                   /note="Lecithin-cholesterol acyltransferase-like 1"
FT                   /id="PRO_0000430055"
FT   ACT_SITE        191
FT                   /note="Acyl-ester intermediate"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        354
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        386
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         411..434
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12869764"
FT                   /id="VSP_055462"
SQ   SEQUENCE   434 AA;  46954 MW;  78C17256980F94F7 CRC64;
     MDLLRRVAVV AVLLSLPSRG RSGGGGSDLH PVVLVPGYGS NRLYARLTAA YEPAAPRCGA
     REGKDEWFQL WPIDAAASEP AQAPCLAEKM SLVYDPVADD YRNVAGVVTR VPSFASTRAL
     VGWDPLVRQL EAMGHRDGGS LFAAPYDFRY AVAPRGHPSA VGERYFARLT RLIERASRLN
     GGRPAVVVAH SFGCALTYQF LRARPLAWRQ RFVKHAVLLA AALGGFAEGM DGLASGAGSG
     LPNLAPPARA RLARSQQSAL WRLPTPMVFG DRPVVVTKNS TYSANNITEF LDAIGFTEGV
     QPYVTRVLPM WRALPAPMVP VTSMYGVGVR TPETFVYGEA GFEGTPEVVY GDGDGNMNIV
     SLMAAEEWSG VEGQILKVVR LPGVSHVGFF SDLALKKVVA EIQKAVSSIE VHRKEKIFSF
     LNNFEFTIPV PLGW