LCBA1_AERHY
ID LCBA1_AERHY Reviewed; 360 AA.
AC Q84BK9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Capsular polysaccharide phosphotransferase LcbA;
DE EC=2.7.-.-;
DE AltName: Full=Stealth protein LcbA;
GN Name=lcbA;
OS Aeromonas hydrophila.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=644;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISCUSSION OF POSSIBLE FUNCTION.
RC STRAIN=PPD11/90 / Serogroup O:21;
RX PubMed=12686647; DOI=10.1099/mic.0.26144-0;
RA Zhang Y.L., Lau Y.L., Arakawa E., Leung K.Y.;
RT "Detection and genetic analysis of group II capsules in Aeromonas
RT hydrophila.";
RL Microbiology 149:1051-1060(2003).
RN [2]
RP IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT "Stealth proteins: in silico identification of a novel protein family
RT rendering bacterial pathogens invisible to host immune defense.";
RL PLoS Comput. Biol. 1:492-499(2005).
CC -!- FUNCTION: Part of a group II capsule biosynthesis locus.
CC -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC conserved from bacteria to higher eukaryotes. Family members were first
CC identified in microbes as proteins that help pathogens to elude the
CC host innate immune system. Microbial stealth proteins are involved in
CC the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC to function as hexose-1-phosphoryltransferases.
CC -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR EMBL; AY144595; AAN10298.1; -; Genomic_DNA.
DR AlphaFoldDB; Q84BK9; -.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR031358; Stealth_CR1.
DR InterPro; IPR021520; Stealth_CR2.
DR Pfam; PF17101; Stealth_CR1; 1.
DR Pfam; PF11380; Stealth_CR2; 1.
PE 3: Inferred from homology;
KW Exopolysaccharide synthesis; Transferase.
FT CHAIN 1..360
FT /note="Capsular polysaccharide phosphotransferase LcbA"
FT /id="PRO_0000235943"
SQ SEQUENCE 360 AA; 42150 MW; 6B41FAA61D5A4997 CRC64;
MRKLKKFFKN PSIFIRDHLN KKYPIVRNEI SCSENEEYIL MRHDLALESQ INIDFPIDVV
FTWVNDADPK WQERYQKYKQ SVDTEHVGRH ALDSARFSNH DELKYSLGCV LKFLPWIRRI
YIVTDKQCPN WLTPNDKIRV IDHSEMIEKQ YLPTFNSHVI EAHLHKIPDL AEHFIYFNDD
VFVARPLPAG HFFRSNGIAS LFMSKKSLST MQAKGTDTPT LSASLKSASL LNHDFSFLID
HPLVHTYVPL RKSMFEECWR LYRADIKRFL PNRFRTNNDL NLATFFIPWL SYIRGVAVPS
RDICYYFNAR SPAAANYFNA LLLAKKNGTL PHSFCANDFN TKNVNPRNNV ANLLSNYFSE