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LCBA1_AERHY
ID   LCBA1_AERHY             Reviewed;         360 AA.
AC   Q84BK9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Capsular polysaccharide phosphotransferase LcbA;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein LcbA;
GN   Name=lcbA;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISCUSSION OF POSSIBLE FUNCTION.
RC   STRAIN=PPD11/90 / Serogroup O:21;
RX   PubMed=12686647; DOI=10.1099/mic.0.26144-0;
RA   Zhang Y.L., Lau Y.L., Arakawa E., Leung K.Y.;
RT   "Detection and genetic analysis of group II capsules in Aeromonas
RT   hydrophila.";
RL   Microbiology 149:1051-1060(2003).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- FUNCTION: Part of a group II capsule biosynthesis locus.
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AY144595; AAN10298.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q84BK9; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..360
FT                   /note="Capsular polysaccharide phosphotransferase LcbA"
FT                   /id="PRO_0000235943"
SQ   SEQUENCE   360 AA;  42150 MW;  6B41FAA61D5A4997 CRC64;
     MRKLKKFFKN PSIFIRDHLN KKYPIVRNEI SCSENEEYIL MRHDLALESQ INIDFPIDVV
     FTWVNDADPK WQERYQKYKQ SVDTEHVGRH ALDSARFSNH DELKYSLGCV LKFLPWIRRI
     YIVTDKQCPN WLTPNDKIRV IDHSEMIEKQ YLPTFNSHVI EAHLHKIPDL AEHFIYFNDD
     VFVARPLPAG HFFRSNGIAS LFMSKKSLST MQAKGTDTPT LSASLKSASL LNHDFSFLID
     HPLVHTYVPL RKSMFEECWR LYRADIKRFL PNRFRTNNDL NLATFFIPWL SYIRGVAVPS
     RDICYYFNAR SPAAANYFNA LLLAKKNGTL PHSFCANDFN TKNVNPRNNV ANLLSNYFSE
 
 
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