ID   LCBA2_AERHY             Reviewed;         364 AA.
AC   Q848R7;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Capsular polysaccharide phosphotransferase LcbA;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein LcbA;
GN   Name=lcbA;
OS   Aeromonas hydrophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=644;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISCUSSION OF POSSIBLE FUNCTION.
RC   STRAIN=JCM 3983 / Serogroup O:21;
RX   PubMed=12686647; DOI=10.1099/mic.0.26144-0;
RA   Zhang Y.L., Lau Y.L., Arakawa E., Leung K.Y.;
RT   "Detection and genetic analysis of group II capsules in Aeromonas
RT   hydrophila.";
RL   Microbiology 149:1051-1060(2003).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- FUNCTION: Part of a group II capsule biosynthesis locus.
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AY177683; AAO59431.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q848R7; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..364
FT                   /note="Capsular polysaccharide phosphotransferase LcbA"
FT                   /id="PRO_0000235944"
SQ   SEQUENCE   364 AA;  42462 MW;  BC78390BC7A92F34 CRC64;
     MRKLKKFFKN PGIFIRDHLN KKYPVIRNEI ECAENEEDIL MRHDLALESK IDIDFPIDVV
     FTWVDDTDPT WQLRYQQHKL QVNAEHVGRY ATDPARFSNH DELRYSLGSV LKFLPWVRRI
     YIVTDQQCPK WLTPSDKIRI VDHTDIIDRQ YLPTFNSHVI EAHLHKIPDL AEHFIYFNDD
     VFVARPLPAG HFFRSNGIAS LFMSNKSLAI MQKKGTDTPT LSASLKSASI LNQDFSFLID
     HPLVHTYVPL RKSIFEESWR LYRADLKSFL SHRFRTNHDL NLATFFVPWL SYIRGVAVPS
     RDICYYFNAR SPAAATYFKA LEIAKQKGTL PHSFCANDFN SKEKTKDSNV TLLLSRYFKD
     AITG