ID   LCBA_NEIMI              Reviewed;         373 AA.
AC   Q51151;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Capsular polysaccharide phosphotransferase;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein;
OS   Neisseria meningitidis serogroup B.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B1940 / Serogroup B;
RX   PubMed=8022265; DOI=10.1111/j.1365-2958.1994.tb00367.x;
RA   Hammerschmidt S., Birkholz C., Zaehringer U., Robertson B.D.,
RA   van Putten J.P.M., Ebeling O., Frosch M.;
RT   "Contribution of genes from the capsule gene complex (cps) to
RT   lipooligosaccharide biosynthesis and serum resistance in Neisseria
RT   meningitidis.";
RL   Mol. Microbiol. 11:885-896(1994).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- FUNCTION: Part of a capsule gene locus. Expression was not detected
CC       under standard growth conditions.
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; L09188; AAA63160.1; -; Genomic_DNA.
DR   PIR; S42434; S42434.
DR   AlphaFoldDB; Q51151; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..373
FT                   /note="Capsular polysaccharide phosphotransferase"
FT                   /id="PRO_0000235955"
SQ   SEQUENCE   373 AA;  44272 MW;  76B373341D661ADA CRC64;
     MNLNKIRKFF RESHIFFRDF LNKRFPPYNV EQPIPETEEF TLINADANLA SLTENVLPNF
     PIDVVFTWVD NTDKAWQEQY YRTLQPIDQE DIGLYATDPA RFSNHNELFY SVQAVQKFMP
     WVRNIFIVTA DQKPKWLDEN IHSKIKLINH SQLIDAKYLP TFNSHVIEAN LYKIPDLSEH
     FIYFNDDVFV ARPLMPNHFF ENNGLASLFV ANKSFQKMRQ RGLITPTLTA SEHALKLLKR
     HYPTININTP LVHTYVPLRK TSFQKAWSLF EDEINSFLNN KVRHNSELNM ASFLIPWLMY
     LDGYATPKRE ICYYFNIRSS HAQTQYKKLL FEKEHLHMPH SFCINDSSSN NADKNYALHF
     RNFMDTYFEI ETE