LCCA_LEUGE
ID LCCA_LEUGE Reviewed; 61 AA.
AC P34034;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Bacteriocin leucocin-A;
DE AltName: Full=Leucocin A-UAL 187;
DE Short=Leu A;
DE Flags: Precursor;
GN Name=lcnA;
OS Leuconostoc gelidum.
OG Plasmid pLG7.6.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=1244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 25-37.
RC STRAIN=UAL 187;
RX PubMed=1840587; DOI=10.1128/jb.173.23.7491-7500.1991;
RA Hastings J.W., Sailer M., Johnson K., Roy K.L., Vederas J.C., Stiles M.E.;
RT "Characterization of leucocin A-UAL 187 and cloning of the bacteriocin gene
RT from Leuconostoc gelidum.";
RL J. Bacteriol. 173:7491-7500(1991).
RN [2]
RP STRUCTURE BY NMR.
RC STRAIN=UAL 187;
RX PubMed=8418850; DOI=10.1021/bi00052a039;
RA Sailer M., Helms G.L., Henkel T., Niemczura W.P., Stiles M.E.,
RA Vederas J.C.;
RT "15N- and 13C-labeled media from Anabaena sp. for universal isotopic
RT labeling of bacteriocins: NMR resonance assignments of leucocin A from
RT Leuconostoc gelidum and nisin A from Lactococcus lactis.";
RL Biochemistry 32:310-318(1993).
RN [3]
RP STRUCTURE BY NMR.
RX PubMed=9398233; DOI=10.1021/bi971263h;
RA Gallagher N.L.F., Sailer M., Niemczura W.P., Nakashima T.T., Stiles M.E.,
RA Vederas J.C.;
RT "Three-dimensional structure of leucocin A in trifluoroethanol and
RT dodecylphosphocholine micelles: spatial location of residues critical for
RT biological activity in type IIa bacteriocins from lactic acid bacteria.";
RL Biochemistry 36:15062-15072(1997).
CC -!- FUNCTION: Inhibits a wide spectrum of lactic acid bacteria.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC {ECO:0000305}.
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DR EMBL; M64371; AAA68003.1; -; Genomic_DNA.
DR PIR; A41657; A41657.
DR PDB; 1CW6; NMR; -; A=25-61.
DR PDB; 2LEU; NMR; -; A=25-61.
DR PDB; 2LJQ; NMR; -; A=25-61.
DR PDB; 2LJT; NMR; -; A=25-61.
DR PDB; 3LEU; NMR; -; A=25-61.
DR PDBsum; 1CW6; -.
DR PDBsum; 2LEU; -.
DR PDBsum; 2LJQ; -.
DR PDBsum; 2LJT; -.
DR PDBsum; 3LEU; -.
DR AlphaFoldDB; P34034; -.
DR SMR; P34034; -.
DR TCDB; 1.C.24.1.6; the pediocin (pediocin) family.
DR EvolutionaryTrace; P34034; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.130; -; 1.
DR InterPro; IPR002633; Bacteriocin_IIa.
DR InterPro; IPR023384; Bacteriocin_IIa_CS.
DR InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR Pfam; PF01721; Bacteriocin_II; 1.
DR PROSITE; PS60030; BACTERIOCIN_IIA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic; Antimicrobial; Bacteriocin;
KW Direct protein sequencing; Disulfide bond; Plasmid; Secreted.
FT PROPEP 1..24
FT /evidence="ECO:0000269|PubMed:1840587"
FT /id="PRO_0000002742"
FT CHAIN 25..61
FT /note="Bacteriocin leucocin-A"
FT /id="PRO_0000002743"
FT DISULFID 33..38
FT STRAND 28..30
FT /evidence="ECO:0007829|PDB:1CW6"
FT STRAND 32..34
FT /evidence="ECO:0007829|PDB:1CW6"
FT STRAND 37..39
FT /evidence="ECO:0007829|PDB:1CW6"
FT HELIX 43..53
FT /evidence="ECO:0007829|PDB:1CW6"
FT STRAND 57..59
FT /evidence="ECO:0007829|PDB:1CW6"
SQ SEQUENCE 61 AA; 6586 MW; 4A645D631486409F CRC64;
MMNMKPTESY EQLDNSALEQ VVGGKYYGNG VHCTKSGCSV NWGEAFSAGV HRLANGGNGF
W
