ID   LCD1_ASHGO              Reviewed;         694 AA.
AC   Q751Y8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=DNA damage checkpoint protein LCD1;
GN   Name=LCD1; OrderedLocusNames=AFR687W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Forms a complex with the serine/threonine kinase MEC1 which
CC       activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1
CC       complex is recruited to DNA lesions in order to initiates the DNA
CC       repair by homologous recombination. Required for cell growth and
CC       meiotic recombination (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with MEC1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016819; AAS54059.1; -; Genomic_DNA.
DR   RefSeq; NP_986235.1; NM_212371.1.
DR   AlphaFoldDB; Q751Y8; -.
DR   SMR; Q751Y8; -.
DR   STRING; 33169.AAS54059; -.
DR   EnsemblFungi; AAS54059; AAS54059; AGOS_AFR687W.
DR   GeneID; 4622524; -.
DR   KEGG; ago:AGOS_AFR687W; -.
DR   eggNOG; ENOG502QQI0; Eukaryota.
DR   HOGENOM; CLU_383646_0_0_1; -.
DR   InParanoid; Q751Y8; -.
DR   OMA; IFQYELI; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0070310; C:ATR-ATRIP complex; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:EnsemblFungi.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0045184; P:establishment of protein localization; IEA:EnsemblFungi.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:EnsemblFungi.
DR   InterPro; IPR018622; DNA_damage_chkpnt_Lcd1.
DR   Pfam; PF09798; LCD1; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; Cytoplasm; DNA damage; DNA repair;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..694
FT                   /note="DNA damage checkpoint protein LCD1"
FT                   /id="PRO_0000227712"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          68..130
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   694 AA;  79452 MW;  6B70155DC5146515 CRC64;
     MSSQWDEDSD ADILELANKP PRGTQLTQIE SHAETETCGN DESGTGARTH EDLDKLQMDL
     MTARGESGML RDRLMMLQQE KDRERERLLG REQELQGRHL QELQKLQEEL QRLEDEKQFL
     VLEKRQLVKG HIAAGLPAQD IQDDSTEVSA KRRKTEDSLV QTYVTLNHTR VVTGDSSLFL
     DHMVLFKLHG SDMTVLDMLD HISLESPASC SMLVIPSGEP LGKPIHMMLL RLKSMHPLDK
     MIDIVLENLA MLIKKIMQGK DCRFAVPFLV AYMHQALSFR PSAVHVHALK DLFQFSSDLA
     IKFQPLLKSP LHASPLELGV EPNIFQYELL DTLSLFYCFD VMELCVKYLL QCSPESQKSF
     FDEIIWKNIT KVMQLSLTIS YKSILNVVFS MVEILRALSE LITPEELSTV QWWDSAISKL
     FQLWNRQVSN ANLHDNDNLH VLPKHNFPGL NRCLGDSTNV HLIEELIDTK AVQAIPEVIY
     RDFPPFSREC KIRIEGWGLQ LHKATVNILQ QLLLRYGKQL AHAELLHQTA KFLCREQELL
     LVVRLTADSH NSDMRITLAE ELIRLLYHAW QEHEEPSKAI TEVQNELIAC LWRVVFGHMS
     NRDPQTQPEL DALLLDSFHG LSLKEQHDLY DDVFDQPAAQ AFLARELAAE NVLRCETQFS
     GCHAYTCREM AKSVLESIIS LEDTDSLFLA MVSE